|Application ||WB, E|
|Calculated MW||45873 Da|
|Antigen Region||213-240 aa|
|Other Names||N-acetyllactosaminide beta-1, 6-N-acetylglucosaminyl-transferase, isoform A, N-acetylglucosaminyltransferase, I-branching enzyme, IGNT, GCNT2, GCNT5, II, NACGT1|
|Target/Specificity||This GCNT2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 213-240 amino acids from the Central region of human GCNT2.|
|Format||Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||GCNT2 Antibody (Center) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Synonyms||GCNT5, II, NACGT1|
|Function||Branching enzyme that converts linear into branched poly-N-acetyllactosaminoglycans. Introduces the blood group I antigen during embryonic development. It is closely associated with the development and maturation of erythroid cells. The expression of the blood group I antigen in erythrocytes is determined by isoform C.|
|Cellular Location||Golgi apparatus membrane; Single-pass type II membrane protein|
|Tissue Location||Isoform B is expressed in lens epithelium cells. Isoform C is expressed in reticulocytes|
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Provided below are standard protocols that you may find useful for product applications.
This gene encodes the enzyme responsible for formation of the blood group I antigen. The i and I antigens are distinguished by linear and branched poly-N-acetyllactosaminoglycans, respectively. The encoded protein is the I-branching enzyme, a beta-1,6-N-acetylglucosaminyltransferase responsible for the conversion of fetal i antigen to adult I antigen in erythrocytes during embryonic development. Mutations in this gene have been associated with adult i blood group phenotype. Alternatively spliced transcript variants encoding different isoforms have been described.
Twu, Y.C., et al. Blood 110(13):4526-4534(2007)
Wang, L., et al. Biochem. Biophys. Res. Commun. 331(4):958-963(2005)
Pras, E., et al. Invest. Ophthalmol. Vis. Sci. 45(6):1940-1945(2004)
Inaba, N., et al. Blood 101(7):2870-2876(2003)
Yu, L.C., et al. Blood 101(6):2081-2088(2003)
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