CTEN Antibody (N-term)
Affinity Purified Rabbit Polyclonal Antibody (Pab)
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application
| WB, E |
---|---|
Primary Accession | Q8IZW8 |
Other Accession | NP_116254.4 |
Reactivity | Human |
Host | Rabbit |
Clonality | Polyclonal |
Isotype | Rabbit IgG |
Calculated MW | 76764 Da |
Antigen Region | 132-159 aa |
Gene ID | 84951 |
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Other Names | Tensin-4, C-terminal tensin-like protein, TNS4, CTEN |
Target/Specificity | This CTEN antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 132-159 amino acids from the N-terminal region of human CTEN. |
Dilution | WB~~1:1000 |
Format | Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification. |
Storage | Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. |
Precautions | CTEN Antibody (N-term) is for research use only and not for use in diagnostic or therapeutic procedures. |
Name | TNS4 |
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Synonyms | CTEN |
Function | Promotes EGF-induced cell migration by displacing tensin TNS3 from the cytoplasmic tail of integrin ITGB1 which results in dissociation of TNS3 from focal adhesions, disassembly of actin stress fibers and initiation of cell migration (PubMed:17643115). Suppresses ligand-induced degradation of EGFR by reducing EGFR ubiquitination in the presence of EGF (PubMed:23774213). Increases MET protein stability by inhibiting MET endocytosis and subsequent lysosomal degradation which leads to increased cell survival, proliferation and migration (PubMed:24814316). |
Cellular Location | Cell junction, focal adhesion. Cytoplasm, cytoskeleton |
Tissue Location | Expressed at low levels in colon (at protein level) (PubMed:19214987, PubMed:19487278). Expressed in prostate and placenta (PubMed:12154022). |
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Provided below are standard protocols that you may find useful for product applications.
Background
TNS4 may be involved in cell migration, cartilage development and in linking signal transduction pathways to the cytoskeleton (By similarity). May promote apoptosis, via its cleavage by caspase-3.
References
Bailey, S.D., et al. Diabetes Care 33(10):2250-2253(2010)
Li, Y., et al. Prostate 70(1):48-60(2010)
Talmud, P.J., et al. Am. J. Hum. Genet. 85(5):628-642(2009)
Liao, Y.C., et al. Cancer Res. 69(11):4563-4566(2009)
Martuszewska, D., et al. PLoS ONE 4 (2), E4350 (2009) :
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