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CTEN Antibody (N-term)

Affinity Purified Rabbit Polyclonal Antibody (Pab)

     
  • WB - CTEN Antibody (N-term) AP18466a
    CTEN Antibody (N-term) (Cat. #AP18466a) western blot analysis in HepG2 cell line lysates (35ug/lane).This demonstrates the CTEN antibody detected the CTEN protein (arrow).
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Product Information
Application
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • E=ELISA
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
WB, E
Primary Accession Q8IZW8
Other Accession NP_116254.4
Reactivity Human
Host Rabbit
Clonality Polyclonal
Isotype Rabbit IgG
Calculated MW 76764 Da
Antigen Region 132-159 aa
Additional Information
Gene ID 84951
Other Names Tensin-4, C-terminal tensin-like protein, TNS4, CTEN
Target/Specificity This CTEN antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 132-159 amino acids from the N-terminal region of human CTEN.
Dilution WB~~1:1000
Format Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.
StorageMaintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
PrecautionsCTEN Antibody (N-term) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name TNS4
Synonyms CTEN
Function Promotes EGF-induced cell migration by displacing tensin TNS3 from the cytoplasmic tail of integrin ITGB1 which results in dissociation of TNS3 from focal adhesions, disassembly of actin stress fibers and initiation of cell migration (PubMed:17643115). Suppresses ligand-induced degradation of EGFR by reducing EGFR ubiquitination in the presence of EGF (PubMed:23774213). Increases MET protein stability by inhibiting MET endocytosis and subsequent lysosomal degradation which leads to increased cell survival, proliferation and migration (PubMed:24814316).
Cellular Location Cell junction, focal adhesion. Cytoplasm, cytoskeleton
Tissue Location Expressed at low levels in colon (at protein level) (PubMed:19214987, PubMed:19487278). Expressed in prostate and placenta (PubMed:12154022).
Research Areas
Citations (0)
citation

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Background

TNS4 may be involved in cell migration, cartilage development and in linking signal transduction pathways to the cytoskeleton (By similarity). May promote apoptosis, via its cleavage by caspase-3.

References

Bailey, S.D., et al. Diabetes Care 33(10):2250-2253(2010)
Li, Y., et al. Prostate 70(1):48-60(2010)
Talmud, P.J., et al. Am. J. Hum. Genet. 85(5):628-642(2009)
Liao, Y.C., et al. Cancer Res. 69(11):4563-4566(2009)
Martuszewska, D., et al. PLoS ONE 4 (2), E4350 (2009) :

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$ 365.00
$ 140.00
Cat# AP18466a
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