|Application ||WB, E|
|Calculated MW||30022 Da|
|Antigen Region||244-270 aa|
|Other Names||Hematopoietically-expressed homeobox protein HHEX, Homeobox protein HEX, Homeobox protein PRH, HHEX, HEX, PRH, PRHX|
|Target/Specificity||This HHEX antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 244-270 amino acids from the C-terminal region of human HHEX.|
|Format||Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.|
|Precautions||HHEX Antibody (C-term) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Synonyms||HEX, PRH, PRHX|
|Function||Recognizes the DNA sequence 5'-ATTAA-3'. Transcriptional repressor. May play a role in hematopoietic differentiation. Establishes anterior identity at two levels; acts early to enhance canonical WNT-signaling by repressing expression of TLE4, and acts later to inhibit NODAL-signaling by directly targeting NODAL (By similarity).|
|Tissue Location||Liver and promyelocytic leukemia cell line HL- 60.|
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Provided below are standard protocols that you may find useful for product applications.
This gene encodes a member of the homeobox family of transcription factors, many of which are involved in developmental processes. Expression in specific hematopoietic lineages suggests that this protein may play a role in hematopoietic differentiation.
Heni, M., et al. Diabetes 59(12):3247-3252(2010)
Pechlivanis, S., et al. Arterioscler. Thromb. Vasc. Biol. 30(9):1867-1872(2010)
Reitz, C., et al. Neurobiol. Aging (2010) In press :
Gaudet, M.M., et al. Cancer Epidemiol. Biomarkers Prev. 19(8):2106-2109(2010)
Gupta, V., et al. Ann. Hum. Genet. 74(4):361-368(2010)
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