|Application ||WB, E|
|Calculated MW||152472 Da|
|Antigen Region||1327-1355 aa|
|Other Names||Ribosome-binding protein 1, 180 kDa ribosome receptor homolog, RRp, ES/130-related protein, Ribosome receptor protein, RRBP1, KIAA1398|
|Target/Specificity||This RRBP1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 1327-1355 amino acids from the C-terminal region of human RRBP1.|
|Format||Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||RRBP1 Antibody (C-term) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Acts as a ribosome receptor and mediates interaction between the ribosome and the endoplasmic reticulum membrane.|
|Cellular Location||Endoplasmic reticulum membrane; Single-pass type III membrane protein|
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Provided below are standard protocols that you may find useful for product applications.
Analysis of cDNA clones indicates that ribosome binding protein 1 may exist in different forms due to removal of tandem repeats, or partial intraexonic splicing of RRBP1. The form presented here is lacking the canine p180 ribosome-binding domain, NQGKKAEGAQ, which is tandemly repeated close to the N-terminus in other forms that haven't been fully characterized. RRBP1 has been excluded as a candidate gene in the cause of Alagille syndrome. Alternate splicing results in multiple transcript variants.
Ueno, T., et al. J. Biol. Chem. 285(39):29941-29950(2010)
Ueno, T., et al. Exp. Cell Res. 316(3):329-340(2010)
Krasnov, G.S., et al. Mol. Biol. (Mosk.) 43(2):348-356(2009)
Benyamini, P., et al. Mol. Biol. Cell 20(2):732-744(2009)
Bai, J.Z., et al. Cell Biol. Int. 32(5):473-483(2008)
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