|Application ||WB, E|
|Calculated MW||27482 Da|
|Antigen Region||27-53 aa|
|Other Names||Interleukin-34, IL-34, IL34, C16orf77|
|Target/Specificity||This IL34 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 27-53 amino acids from the N-terminal region of human IL34.|
|Format||Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||IL34 Antibody (N-term) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Cytokine that promotes the proliferation, survival and differentiation of monocytes and macrophages. Promotes the release of proinflammatory chemokines, and thereby plays an important role in innate immunity and in inflammatory processes. Plays an important role in the regulation of osteoclast proliferation and differentiation, and in the regulation of bone resorption. Signaling via CSF1R and its downstream effectors stimulates phosphorylation of MAPK1/ERK2 AND MAPK3/ERK1.|
|Tissue Location||Detected in the sinusoidal epithelium in the red pulp of spleen (at protein level). Predominantly expressed in spleen. Also detected in a range of other tissues including heart, brain, lung, liver, kidney, thymus, testis, ovary, small intestine, prostate and colon.|
Thousands of laboratories across the world have published research that depended on the performance of antibodies from Abgent to advance their research. Check out links to articles that cite our products in major peer-reviewed journals, organized by research category.
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Provided below are standard protocols that you may find useful for product applications.
Interleukin-34 is a cytokine that promotes the differentiation and viability of monocytes and macrophages through the colony-stimulating factor-1 receptor (CSF1R; MIM 164770) (Lin et al., 2008 [PubMed 18467591]).
Wei, S., et al. J. Leukoc. Biol. 88(3):495-505(2010)
Lin, H., et al. Science 320(5877):807-811(2008)
Lim, J., et al. Cell 125(4):801-814(2006)
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