|Application ||WB, E|
|Calculated MW||36939 Da|
|Antigen Region||57-85 aa|
|Other Names||T-cell surface glycoprotein CD1b, CD1b, CD1B|
|Target/Specificity||This CD1B antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 57-85 amino acids from the N-terminal region of human CD1B.|
|Format||Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||CD1B Antibody (N-term) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Antigen-presenting protein that binds self and non-self lipid and glycolipid antigens and presents them to T-cell receptors on natural killer T-cells.|
|Cellular Location||Cell membrane; Single- pass type I membrane protein. Endosome membrane; Single-pass type I membrane protein. Lysosome membrane; Single- pass type I membrane protein. Note=Subject to intracellular trafficking between the cell membrane, endosomes and lysosomes.|
|Tissue Location||Expressed on cortical thymocytes, on certain T-cell leukemias, and in various other tissues|
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Provided below are standard protocols that you may find useful for product applications.
This gene encodes a member of the CD1 family of transmembrane glycoproteins, which are structurally related to the major histocompatibility complex (MHC) proteins and form heterodimers with beta-2-microglobulin. The CD1 proteins mediate the presentation of primarily lipid and glycolipid antigens of self or microbial origin to T cells. The human genome contains five CD1 family genes organized in a cluster on chromosome 1. The CD1 family members are thought to differ in their cellular localization and specificity for particular lipid ligands. The protein encoded by this gene localizes to late endosomes and lysosomes via a tyrosine-based motif in the cytoplasmic tail, and requires vesicular acidification to bind lipid antigens. [provided by RefSeq].
Davila, S., et al. Genes Immun. 11(3):232-238(2010)
Felio, K., et al. J. Exp. Med. 206(11):2497-2509(2009)
Guiard, J., et al. J. Immunol. 182(11):7030-7037(2009)
Cui, Y., et al. Biol. Direct 4, 47 (2009) :
Zajonc, D.M., et al. Proc. Natl. Acad. Sci. U.S.A. 105(46):17925-17930(2008)
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