|Application ||WB, E|
|Other Accession||Q9WTW3, NP_542402.2|
|Calculated MW||23806 Da|
|Antigen Region||58-86 aa|
|Other Names||Potassium voltage-gated channel subfamily E member 4, MinK-related peptide 3, Minimum potassium ion channel-related peptide 3, Potassium channel subunit beta MiRP3, KCNE4|
|Target/Specificity||This KCNE4 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 58-86 amino acids from the Central region of human KCNE4.|
|Format||Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||KCNE4 Antibody (Center) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Ancillary protein that assembles as a beta subunit with a voltage-gated potassium channel complex of pore-forming alpha subunits. Modulates the gating kinetics and enhances stability of the channel complex. May associate with KCNQ1/KVLTQ1 and inhibit potassium current.|
|Cellular Location||Membrane; Single-pass membrane protein|
|Tissue Location||Predominantly expressed in embryo and adult uterus. Low expression found in kidney, small intestine, lung and heart.|
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Provided below are standard protocols that you may find useful for product applications.
Voltage-gated potassium (Kv) channels represent the most complex class of voltage-gated ion channels from both functional and structural standpoints. Their diverse functions include regulating neurotransmitter release, heart rate, insulin secretion, neuronal excitability, epithelial electrolyte transport, smooth muscle contraction, and cell volume. This gene encodes a member of the potassium channel, voltage-gated, isk-related subfamily. This member is a type I membrane protein, and a beta subunit that assembles with a potassium channel alpha-subunit to modulate the gating kinetics and enhance stability of the multimeric complex. This gene is prominently expressed in the embryo and in adult uterus.
Levy, D.I., et al. J. Physiol. (Lond.) 588 (PT 14), 2657-2668 (2010) :
Sole, L., et al. J. Cell. Sci. 122 (PT 20), 3738-3748 (2009) :
Trevino, L.R., et al. Nat. Genet. 41(9):1001-1005(2009)
Manderfield, L.J., et al. J. Physiol. (Lond.) 587 (PT 2), 303-314 (2009) :
Levy, D.I., et al. Am. J. Physiol. Renal Physiol. 295 (2), F380-F387 (2008) :
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