|Application ||WB, E|
|Other Accession||Q8C031, NP_065980.1|
|Calculated MW||71950 Da|
|Antigen Region||316-343 aa|
|Other Names||Leucine-rich repeat-containing protein 4C, Netrin-G1 ligand, NGL-1, LRRC4C, KIAA1580, NGL1|
|Target/Specificity||This LRRC4C antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 316-343 amino acids from the Central region of human LRRC4C.|
|Format||Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||LRRC4C Antibody (Center) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||May promote neurite outgrowth of developing thalamic neurons.|
|Cellular Location||Cell junction, synapse, postsynaptic cell membrane; Single-pass type I membrane protein|
|Tissue Location||Highly expressed in the cerebral cortex, including frontal, parietal and occipital lobes. Putamen, amygdala, hippocampus and medulla oblongata show moderate expression. Caudate nucleus and thalamus express small amounts, whereas other brain regions show very weak or no expression|
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Provided below are standard protocols that you may find useful for product applications.
NGL1 is a specific binding partner for netrin G1 (NTNG1; MIM 608818), which is a member of the netrin family of axon guidance molecules (Lin et al., 2003 [PubMed 14595443]).[supplied by OMIM].
Rose, J.E., et al. Mol. Med. 16 (7-8), 247-253 (2010) :
Sokolowski, M., et al. Mol. Psychiatry 15(1):10-11(2010)
Hsu, Y.H., et al. PLoS Genet. 6 (6), E1000977 (2010) :
Lin, J.C., et al. Nat. Neurosci. 6(12):1270-1276(2003)
Clark, H.F., et al. Genome Res. 13(10):2265-2270(2003)
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