|Application ||WB, E|
|Calculated MW||40620 Da|
|Antigen Region||242-268 aa|
|Other Names||Peptidoglycan recognition protein 4, Peptidoglycan recognition protein I-beta, PGLYRPIbeta, PGRP-I-beta, Peptidoglycan recognition protein intermediate beta, PGLYRP4, PGRPIB|
|Target/Specificity||This PGLYRP4 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 242-268 amino acids from the Central region of human PGLYRP4.|
|Format||Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||PGLYRP4 Antibody (Center) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Pattern receptor that binds to murein peptidoglycans (PGN) of Gram-positive bacteria. Has bactericidal activity towards Gram-positive bacteria. May kill Gram-positive bacteria by interfering with peptidoglycan biosynthesis. Binds also to Gram- negative bacteria, and has bacteriostatic activity towards Gram- negative bacteria. Plays a role in innate immunity.|
|Tissue Location||Detected in skin epidermis, eccrine sweat glands and ducts, mucous cells in the submandibular salivary gland, mucous cells in the throat, ciliary body epithelial cells of the eye, small intestine, colon, stomach and in mature epithelial cells of the tongue (at protein level). High expression in skin and esophagus. Expressed also to a much lesser extent in the tonsils and thymus.|
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Provided below are standard protocols that you may find useful for product applications.
Peptidoglycan recognition proteins, such as PGRPI-beta, are part of the innate immune system and recognize peptidoglycan, a ubiquitous component of bacterial cell walls.
Rose, J.E., et al. Mol. Med. 16 (7-8), 247-253 (2010) :
Davila, S., et al. Genes Immun. 11(3):232-238(2010)
Cho, S., et al. Proc. Natl. Acad. Sci. U.S.A. 104(21):8761-8766(2007)
Lu, X., et al. J. Biol. Chem. 281(9):5895-5907(2006)
Sun, C., et al. Hum. Genet. 119 (1-2), 113-125 (2006) :
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