RANBP17 Antibody (N-term)
Affinity Purified Rabbit Polyclonal Antibody (Pab)
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application
| WB, E |
---|---|
Primary Accession | Q9H2T7 |
Other Accession | Q99NF8, NP_075048.1 |
Reactivity | Human, Mouse |
Host | Rabbit |
Clonality | Polyclonal |
Isotype | Rabbit IgG |
Calculated MW | 124375 Da |
Antigen Region | 149-175 aa |
Gene ID | 64901 |
---|---|
Other Names | Ran-binding protein 17, RANBP17 |
Target/Specificity | This RANBP17 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 149-175 amino acids from the N-terminal region of human RANBP17. |
Dilution | WB~~1:1000 |
Format | Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification. |
Storage | Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. |
Precautions | RANBP17 Antibody (N-term) is for research use only and not for use in diagnostic or therapeutic procedures. |
Name | RANBP17 |
---|---|
Function | May function as a nuclear transport receptor. |
Cellular Location | Cytoplasm. Nucleus. Nucleus, nuclear pore complex |
Tissue Location | Highly expressed in testis, moderately in pancreas and weakly in other tissues studied. |
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Provided below are standard protocols that you may find useful for product applications.
Background
The transport of protein and large RNAs through the nuclear pore complexes (NPC) is an energy-dependent and regulated process. The import of proteins with a nuclear localization signal (NLS) is accomplished by recognition of one or more clusters of basic amino acids by the importin-alpha/beta complex; see MIM 600685 and MIM 602738. The small GTPase RAN (MIM 601179) plays a key role in NLS-dependent protein import. RAN-binding protein-17 is a member of the importin-beta superfamily of nuclear transport receptors.
References
Bailey, S.D., et al. Diabetes Care 33(10):2250-2253(2010)
Talmud, P.J., et al. Am. J. Hum. Genet. 85(5):628-642(2009)
Kutay, U., et al. J. Biol. Chem. 275(51):40163-40168(2000)
Koch, P., et al. Biochem. Biophys. Res. Commun. 278(1):241-249(2000)
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