|Application ||WB, E|
|Other Accession||Q99NF8, NP_075048.1|
|Calculated MW||124375 Da|
|Antigen Region||149-175 aa|
|Other Names||Ran-binding protein 17, RANBP17|
|Target/Specificity||This RANBP17 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 149-175 amino acids from the N-terminal region of human RANBP17.|
|Format||Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||RANBP17 Antibody (N-term) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||May function as a nuclear transport receptor.|
|Cellular Location||Cytoplasm. Nucleus. Nucleus, nuclear pore complex|
|Tissue Location||Highly expressed in testis, moderately in pancreas and weakly in other tissues studied|
Thousands of laboratories across the world have published research that depended on the performance of antibodies from Abgent to advance their research. Check out links to articles that cite our products in major peer-reviewed journals, organized by research category.
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Provided below are standard protocols that you may find useful for product applications.
The transport of protein and large RNAs through the nuclear pore complexes (NPC) is an energy-dependent and regulated process. The import of proteins with a nuclear localization signal (NLS) is accomplished by recognition of one or more clusters of basic amino acids by the importin-alpha/beta complex; see MIM 600685 and MIM 602738. The small GTPase RAN (MIM 601179) plays a key role in NLS-dependent protein import. RAN-binding protein-17 is a member of the importin-beta superfamily of nuclear transport receptors.
Bailey, S.D., et al. Diabetes Care 33(10):2250-2253(2010)
Talmud, P.J., et al. Am. J. Hum. Genet. 85(5):628-642(2009)
Kutay, U., et al. J. Biol. Chem. 275(51):40163-40168(2000)
Koch, P., et al. Biochem. Biophys. Res. Commun. 278(1):241-249(2000)
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