|Application ||WB, IF, IHC-P, E|
|Calculated MW||78151 Da|
|Antigen Region||120-152 aa|
|Other Names||UV radiation resistance-associated gene protein, p63, UVRAG|
|Target/Specificity||This UVRAG antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 120-152 amino acids from human UVRAG.|
|Format||Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||UVRAG Antibody (L133) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Cellular Location||Late endosome. Lysosome. Early endosome. Note=Colocalizes with RAB9-positive compartments involved in retrograde transport from late endosomes to trans-Golgi network. Colocalization with early endosomes is only partial|
|Tissue Location||Highly expressed in brain, lung, kidney and liver.|
Thousands of laboratories across the world have published research that depended on the performance of antibodies from Abgent to advance their research. Check out links to articles that cite our products in major peer-reviewed journals, organized by research category.
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Provided below are standard protocols that you may find useful for product applications.
UVRAG complements the ultraviolet sensitivity of xeroderma pigmentosum group C cells and encodes a protein with a C2 domain. The protein activates the Beclin1-PI(3)KC3 complex, promoting autophagy and suppressing the proliferation and tumorigenicity of human colon cancer cells. Chromosomal aberrations involving this gene are associated with left-right axis malformation and mutations in this gene have been associated with colon cancer.
Liang,C., et al. Nat. Cell Biol. 8 (7), 688-699 (2006)
Ionov,Y., et al. Oncogene 23 (3), 639-645 (2004)
Goi,T., et al. Surg. Today 33 (9), 702-706 (2003)
Iida,A., et al. Hum. Genet. 106 (3), 277-287 (2000)
Perelman,B., et al. Genomics 41 (3), 397-405 (1997)
Bekri,S., et al. Cytogenet. Cell Genet. 79 (1-2), 125-131 (1997)
Teitz,T., et al. Gene 87 (2), 295-298 (1990)
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