|Application ||WB, E|
|Other Accession||O35652, NP_001001933.1|
|Calculated MW||39301 Da|
|Antigen Region||205-232 aa|
|Other Names||LIM/homeobox protein Lhx8, LIM homeobox protein 8, LHX8|
|Target/Specificity||This LHX8 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 205-232 amino acids from the Central region of human LHX8.|
|Format||Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||LHX8 Antibody (Center) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Transcription factor involved in differentiation of certain neurons and mesenchymal cells.|
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Provided below are standard protocols that you may find useful for product applications.
Members of the LIM homeobox gene family, such as LHX8, encode transcription regulators that share common structural features. They all contain 2 tandemly repeated cysteine-rich double-zinc finger motifs, called LIM domains, in addition to a homeodomain. The homeodomain is a DNA-binding domain, and the LIM domains are essential for regulating the activity of these molecules by interacting with other proteins. Members of the LIM homeobox gene family are required for the patterning or the specification and differentiation of different cell types during embryonic development (Zhao et al., 1999 [PubMed 10611327]).
Nikopensius, T., et al. Birth Defects Res. Part A Clin. Mol. Teratol. 88(9):748-756(2010)
Jagomagi, T., et al. Eur. J. Oral Sci. 118(3):213-220(2010)
Jugessur, A., et al. PLoS ONE 5 (7), E11493 (2010) :
Vieira, A.R., et al. Genet. Med. 10(9):668-674(2008)
Qin, Y., et al. Fertil. Steril. 89(4):1012-1014(2008)
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