|Application ||WB, E|
|Other Accession||P55288, NP_001788|
|Calculated MW||87965 Da|
|Antigen Region||622-650 aa|
|Other Names||Cadherin-11, OSF-4, Osteoblast cadherin, OB-cadherin, CDH11|
|Target/Specificity||This CDH11 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 622-650 amino acids from the C-terminal region of human CDH11.|
|Format||Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||CDH11 Antibody (C-term) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Cadherins are calcium-dependent cell adhesion proteins. They preferentially interact with themselves in a homophilic manner in connecting cells; cadherins may thus contribute to the sorting of heterogeneous cell types.|
|Cellular Location||Cell membrane; Single-pass type I membrane protein|
|Tissue Location||Expressed mainly in brain but also found in other tissues. Expressed in neuroblasts|
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Provided below are standard protocols that you may find useful for product applications.
This gene encodes a type II classical cadherin from the cadherin superfamily, integral membrane proteins that mediate calcium-dependent cell-cell adhesion. Mature cadherin proteins are composed of a large N-terminal extracellular domain, a single membrane-spanning domain, and a small, highly conserved C-terminal cytoplasmic domain. Type II (atypical) cadherins are defined based on their lack of a HAV cell adhesion recognition sequence specific to type I cadherins. Expression of this particular cadherin in osteoblastic cell lines, and its upregulation during differentiation, suggests a specific function in bone development and maintenance.
Rose, J.E., et al. Mol. Med. 16 (7-8), 247-253 (2010) :
Sachdeva, M., et al. Cancer Res. 70(1):378-387(2010)
Canova, C., et al. Cancer Res. 69(7):2956-2965(2009)
Farina, A.K., et al. PLoS ONE 4 (3), E4797 (2009) :
Brieger, J., et al. APMIS 116(12):1050-1057(2008)
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