|Application ||WB, E|
|Other Accession||Q6P8H8, Q0P5D9, NP_076984.2|
|Calculated MW||60088 Da|
|Antigen Region||15-41 aa|
|Other Names||Probable dolichyl pyrophosphate Glc1Man9GlcNAc2 alpha-1, 3-glucosyltransferase, Asparagine-linked glycosylation protein 8 homolog, Dol-P-Glc:Glc(1)Man(9)GlcNAc(2)-PP-dolichyl alpha-1, 3-glucosyltransferase, Dolichyl-P-Glc:Glc1Man9GlcNAc2-PP-dolichyl glucosyltransferase, ALG8|
|Target/Specificity||This ALG8 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 15-41 amino acids from the N-terminal region of human ALG8.|
|Format||Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||ALG8 Antibody (N-term) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Adds the second glucose residue to the lipid-linked oligosaccharide precursor for N-linked glycosylation. Transfers glucose from dolichyl phosphate glucose (Dol-P-Glc) onto the lipid-linked oligosaccharide Glc(1)Man(9)GlcNAc(2)-PP-Dol (By similarity).|
|Cellular Location||Endoplasmic reticulum membrane; Multi-pass membrane protein|
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Provided below are standard protocols that you may find useful for product applications.
This gene encodes a member of the ALG6/ALG8 glucosyltransferase family. The encoded protein catalyzes the addition of the second glucose residue to the lipid-linked oligosaccharide precursor for N-linked glycosylation of proteins. Mutations in this gene have been associated with congenital disorder of glycosylation type Ih (CDG-Ih). Alternatively spliced transcript variants encoding different isoforms have been identified.
Rose, J.E., et al. Mol. Med. 16 (7-8), 247-253 (2010) :
Stolting, T., et al. Mol. Genet. Metab. 98(3):305-309(2009)
Jaeken, J., et al. Curr. Opin. Pediatr. 16(4):434-439(2004)
Schollen, E., et al. J. Med. Genet. 41(7):550-556(2004)
Jaeken, J. J. Inherit. Metab. Dis. 27(3):423-426(2004)
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