|Application ||WB, E|
|Calculated MW||79902 Da|
|Antigen Region||5-31 aa|
|Other Names||cAMP-specific 3', 5'-cyclic phosphodiesterase 4C, DPDE1, PDE21, PDE4C, DPDE1|
|Target/Specificity||This PDE4C antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 5-31 amino acids from the N-terminal region of human PDE4C.|
|Format||Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||PDE4C Antibody (N-term) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Hydrolyzes the second messenger cAMP, which is a key regulator of many important physiological processes.|
|Cellular Location||Cell projection, cilium.|
|Tissue Location||Expressed in various tissues but not in cells of the immune system|
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Provided below are standard protocols that you may find useful for product applications.
Cyclic nucleotides are important second messengers that regulate and mediate a number of cellular responses to extracellular signals, such as hormones, light, and neurotransmitters. Cyclic nucleotide phosphodiesterases (PDEs) regulate the cellular concentrations of cyclic nucleotides and thereby play a role in signal transduction. PDE4C is a class IV cAMP-specific PDE (summary by Milatovich et al., 1994 [PubMed 8009369]).
Bailey, S.D., et al. Diabetes Care 33(10):2250-2253(2010)
Davila, S., et al. Genes Immun. 11(3):232-238(2010)
Talmud, P.J., et al. Am. J. Hum. Genet. 85(5):628-642(2009)
Beausoleil, S.A., et al. Proc. Natl. Acad. Sci. U.S.A. 101(33):12130-12135(2004)
Sullivan, M., et al. Cell. Signal. 11(10):735-742(1999)
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