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>   home   >   Products   >   Primary Antibodies   >   Signal Transduction   >   RNF111 Antibody (N-term)   

RNF111 Antibody (N-term)

Peptide Affinity Purified Rabbit Polyclonal Antibody (Pab)

  • WB - RNF111 Antibody (N-term) AP18547a
    RNF111 Antibody (N-term) (Cat. #AP18547a) western blot analysis in A549 cell line lysates (35ug/lane).This demonstrates the RNF111 antibody detected the RNF111 protein (arrow).
Product Information
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
Primary Accession Q6ZNA4
Other Accession NP_060080.6
Reactivity Human
Host Rabbit
Clonality Polyclonal
Isotype Rabbit Ig
Calculated MW 108862 Da
Antigen Region 209-237 aa
Additional Information
Gene ID 54778
Other Names E3 ubiquitin-protein ligase Arkadia, 632-, RING finger protein 111, RNF111
Target/Specificity This RNF111 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 209-237 amino acids from the N-terminal region of human RNF111.
Dilution WB~~1:1000
Format Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.
StorageMaintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
PrecautionsRNF111 Antibody (N-term) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name RNF111
Function Acts in the NODAL pathway of mesoderm patterning during embryonic development. Acts downstream AXIN1 as an E3 ubiquitin- protein ligase which promotes the ubiquitination of inhibitory SMADs such as SMAD7, induces their proteasomal degradation and thereby enhances the transcriptional activity of TGF-beta and BMP. Activates Smad3/Smad4-dependent transcription by triggering signal-induced SnoN degradation. Associates with UBE2D2 as an E2 enzyme.
Cellular Location Nucleus. Cytoplasm. Note=Upon TGF-beta treatment, translocates from nucleus to cytosol
Tissue Location Broadly expressed.
Research Areas
Citations (0)

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The protein encoded by this gene contains a RING finger domain, a motif known to be involved in protein-protein and protein-DNA interactions. The mouse counterpart of this gene (Rnf111/arkadia) has been shown to genetically interact with the transforming growth factor (TGF) beta-like factor Nodal, and act as a modulator of the nodal signaling cascade, which is essential for the induction of mesoderm during embryonic development. [provided by RefSeq].


Nagano, Y., et al. J. Biochem. 147(4):545-554(2010)
Cunnington, R.H., et al. Can. J. Physiol. Pharmacol. 87(10):764-772(2009)
Markson, G., et al. Genome Res. 19(10):1905-1911(2009)
van Wijk, S.J., et al. Mol. Syst. Biol. 5, 295 (2009) :
Liu, F.Y., et al. Kidney Int. 73(5):588-594(2008)

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$ 295.00
$ 99.00
Cat# AP18547a
(40 western blots)
Availability: In Stock
Bulk Size
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