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>   home   >   Products   >   Primary Antibodies   >   Cell Biology   >   RNF41 Antibody (C-term)   

RNF41 Antibody (C-term)

Peptide Affinity Purified Rabbit Polyclonal Antibody (Pab)

  • WB - RNF41 Antibody (C-term) AP18548b
    RNF41 Antibody (C-term) (Cat. #AP18548b) western blot analysis in 293 cell line lysates (35ug/lane).This demonstrates the RNF41 antibody detected the RNF41 protein (arrow).
Product Information
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
Primary Accession Q9H4P4
Other Accession Q5FWL3, Q8BH75, Q7ZW16, NP_005776.1
Reactivity Human
Predicted Zebrafish, Mouse, Xenopus
Host Rabbit
Clonality Polyclonal
Isotype Rabbit Ig
Calculated MW 35905 Da
Antigen Region 255-281 aa
Additional Information
Gene ID 10193
Other Names E3 ubiquitin-protein ligase NRDP1, 632-, RING finger protein 41, RNF41, FLRF, NRDP1
Target/Specificity This RNF41 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 255-281 amino acids from the C-terminal region of human RNF41.
Dilution WB~~1:1000
Format Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.
StorageMaintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
PrecautionsRNF41 Antibody (C-term) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name RNF41
Synonyms FLRF, NRDP1
Function Acts as E3 ubiquitin-protein ligase and regulates the degradation of target proteins. Polyubiquitinates MYD88. Negatively regulates MYD88-dependent production of proinflammatory cytokines. Can promote TRIF-dependent production of type I interferon and inhibits infection with vesicular stomatitis virus (By similarity). Promotes also activation of TBK1 and IRF3. Involved in the ubiquitination of erythropoietin (EPO) and interleukin-3 (IL-3) receptors. Thus, through maintaining basal levels of cytokine receptors, RNF41 is involved in the control of hematopoietic progenitor cell differentiation into myeloerythroid lineages (By similarity). Contributes to the maintenance of steady-state ERBB3 levels by mediating its growth factor- independent degradation. Involved in the degradation of the inhibitor of apoptosis BIRC6 and thus is an important regulator of cell death by promoting apoptosis. Acts also as a PARK2 modifier that accelerates its degradation, resulting in a reduction of PARK2 activity, influencing the balance of intracellular redox state. The RNF41-PARK2 pathway regulates autophagosome-lysosome fusion during late mitophagy. Mitophagy is a selective form of autophagy necessary for mitochondrial quality control (PubMed:24949970).
Tissue Location Detected in ovary, testis and prostate.
Research Areas
Citations (0)

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The protein encoded by this gene contains a RING finger, a motif present in a variety of functionally distinct proteins and known to be involved in protein-protein and protein-DNA interactions. The specific function of this protein has not yet been determined. Three alternatively spliced transcript variants encoding two distinct isoforms have been reported. [provided by RefSeq].


Ingalla, E.Q., et al. J. Biol. Chem. 285(37):28691-28697(2010)
Chen, L., et al. Cancer Res. 70(14):5994-6003(2010)
Mo, X., et al. Parkinsonism Relat. Disord. 16(3):222-224(2010)
Aharinejad, S., et al. Transplantation 89(2):245-252(2010)
Yu, F., et al. Neurosci. Lett. 440(1):4-8(2008)

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$ 295.00
$ 99.00
Cat# AP18548b
(40 western blots)
Availability: In Stock
Bulk Size
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