|Application ||WB, E|
|Other Accession||A1L1A6, NP_116121.2|
|Calculated MW||86240 Da|
|Antigen Region||103-131 aa|
|Other Names||Interleukin-17 receptor C, IL-17 receptor C, IL-17RC, Interleukin-17 receptor homolog, IL17Rhom, Interleukin-17 receptor-like protein, IL-17RL, ZcytoR14, IL17RC|
|Target/Specificity||This IL17RC antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 103-131 amino acids from the N-terminal region of human IL17RC.|
|Format||Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||IL17RC Antibody (N-term) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Receptor for IL17A and IL17F homodimers as part of a heterodimeric complex with IL17RA (PubMed:16785495). Receptor for the heterodimer formed by IL17A and IL17B as part of a heterodimeric complex with IL17RA (PubMed:18684971). Has also been shown to be the cognate receptor for IL17F and to bind IL17A with high affinity without the need for IL17RA (PubMed:17911633). Activation of IL17RC leads to induction of expression of inflammatory chemokines and cytokines such as CXCL1 (PubMed:16785495).|
|Cellular Location||Cell membrane; Single-pass type I membrane protein. Note=Soluble isoforms may be produced|
|Tissue Location||Expressed in prostate, skeletal muscle, kidney and placenta (at protein level) (PubMed:11706037). Expressed in brain, cartilage, colon, heart, intestine, kidney, liver, lung, muscle, placenta, and prostate (PubMed:11706037). Also detected in thyroid, trachea and adrenal gland (PubMed:17911633). Low expression in thymus and leukocytes (PubMed:11706037)|
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Provided below are standard protocols that you may find useful for product applications.
This gene encodes a single-pass transmembrane protein that shares limited similarity with the interleukin-17 receptor. Multiple alternatively spliced transcript variants encoding different isoforms have been detected for this gene, but the full-length nature of only three have been determined to date.
Pickens, S.R., et al. J. Immunol. 184(6):3233-3241(2010)
Wright, J.F., et al. J. Immunol. 181(4):2799-2805(2008)
Zrioual, S., et al. J. Immunol. 180(1):655-663(2008)
Kuestner, R.E., et al. J. Immunol. 179(8):5462-5473(2007)
Haudenschild, D.R., et al. Prostate 66(12):1268-1274(2006)
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