|Application ||WB, E|
|Other Accession||A1L1A6, NP_116121.2|
|Calculated MW||86240 Da|
|Antigen Region||103-131 aa|
|Other Names||Interleukin-17 receptor C, IL-17 receptor C, IL-17RC, Interleukin-17 receptor homolog, IL17Rhom, Interleukin-17 receptor-like protein, IL-17RL, ZcytoR14, IL17RC|
|Target/Specificity||This IL17RC antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 103-131 amino acids from the N-terminal region of human IL17RC.|
|Format||Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||IL17RC Antibody (N-term) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Receptor for IL17A and IL17F homodimers as part of a heterodimeric complex with IL17RA (PubMed:16785495). Receptor for the heterodimer formed by IL17A and IL17B as part of a heterodimeric complex with IL17RA (PubMed:18684971). Has also been shown to be the cognate receptor for IL17F and to bind IL17A with high affinity without the need for IL17RA (PubMed:17911633). Activation of IL17RC leads to induction of expression of inflammatory chemokines and cytokines such as CXCL1 (PubMed:16785495).|
|Cellular Location||Cell membrane; Single-pass type I membrane protein. Note=Soluble isoforms may be produced|
|Tissue Location||Expressed in prostate, skeletal muscle, kidney and placenta (at protein level) (PubMed:11706037). Expressed in brain, cartilage, colon, heart, intestine, kidney, liver, lung, muscle, placenta, and prostate (PubMed:11706037). Also detected in thyroid, trachea and adrenal gland (PubMed:17911633). Low expression in thymus and leukocytes (PubMed:11706037)|
Thousands of laboratories across the world have published research that depended on the performance of antibodies from Abgent to advance their research. Check out links to articles that cite our products in major peer-reviewed journals, organized by research category.
firstname.lastname@example.org, and receive a free "I Love Antibodies" mug.
Provided below are standard protocols that you may find useful for product applications.
This gene encodes a single-pass transmembrane protein that shares limited similarity with the interleukin-17 receptor. Multiple alternatively spliced transcript variants encoding different isoforms have been detected for this gene, but the full-length nature of only three have been determined to date.
Pickens, S.R., et al. J. Immunol. 184(6):3233-3241(2010)
Wright, J.F., et al. J. Immunol. 181(4):2799-2805(2008)
Zrioual, S., et al. J. Immunol. 180(1):655-663(2008)
Kuestner, R.E., et al. J. Immunol. 179(8):5462-5473(2007)
Haudenschild, D.R., et al. Prostate 66(12):1268-1274(2006)
If you have used an Abgent product and would like to share how it has performed, please click on the "Submit Review" button and provide the requested information. Our staff will examine and post your review and contact you if needed.
If you have any additional inquiries please email technical services at email@example.com.