|Application ||WB, E|
|Other Accession||D3ZWE7, E2IUK4, Q9D5T7, Q4R8B9, Q2KIY6, NP_115508.2|
|Predicted||Bovine, Monkey, Mouse, Pig, Rat|
|Calculated MW||45200 Da|
|Antigen Region||161-189 aa|
|Other Names||HORMA domain-containing protein 1, Cancer/testis antigen 46, CT46, Newborn ovary HORMA protein, HORMAD1, NOHMA|
|Target/Specificity||This HORMAD1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 161-189 amino acids from the Central region of human HORMAD1.|
|Format||Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||HORMAD1 Antibody (Center) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Plays a key role in meiotic progression. Regulates 3 different functions during meiosis: ensures that sufficient numbers of processed DNA double-strand breaks (DSBs) are available for successful homology search by increasing the steady-state numbers of single-stranded DSB ends. Promotes synaptonemal-complex formation independently of its role in homology search. Plays a key role in the male mid-pachytene checkpoint and the female meiotic prophase checkpoint: required for efficient build-up of ATR activity on unsynapsed chromosome regions, a process believed to form the basis of meiotic silencing of unsynapsed chromatin (MSUC) and meiotic prophase quality control in both sexes (By similarity).|
|Cellular Location||Nucleus. Chromosome. Note=Preferentially localizes to unsynapsed or desynapsed chromosomal regions during the prophase I stage of meiosis. TRIP13 is required for depletion from synapsed chromosomes. The expression of the phosphorylated form at Ser-377 is restricted to unsynapsed chromosomal regions (By similarity)|
|Tissue Location||Testis-specific. Over-expressed in carcinomas.|
Thousands of laboratories across the world have published research that depended on the performance of antibodies from Abgent to advance their research. Check out links to articles that cite our products in major peer-reviewed journals, organized by research category.
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Provided below are standard protocols that you may find useful for product applications.
HORMAD1 may monitor and regulate pairing, synapsis, or recombination between homologous chromosomes during meiosis (By similarity).
Chen, Y.T., et al. Cancer Immun. 5, 9 (2005) :
Pangas, S.A., et al. Gene Expr. Patterns 5(2):257-263(2004)
Simpson, J.C., et al. EMBO Rep. 1(3):287-292(2000)
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