|Application ||WB, E|
|Calculated MW||175639 Da|
|Antigen Region||1345-1372 aa|
|Other Names||Synaptonemal complex protein 2, SCP-2, Synaptonemal complex lateral element protein, hsSCP2, SYCP2, SCP2|
|Target/Specificity||This SYCP2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 1345-1372 amino acids from the C-terminal region of human SYCP2.|
|Format||Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||SYCP2 Antibody (C-term) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Major component of the axial/lateral elements of synaptonemal complexes (SCS) during meiotic prophase. May be involved in the organization of chromatin by temporarily binding to DNA scaffold attachment regions. Requires SYCP3, but not SYCP1, in order to be incorporated into the axial/lateral elements (By similarity).|
|Cellular Location||Nucleus. Chromosome. Note=In axial/lateral elements of the tripartite segments of synaptonemal complexes.|
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Provided below are standard protocols that you may find useful for product applications.
The synaptonemal complex is a proteinaceous structure that links homologous chromosomes during the prophase of meiosis. The protein encoded by this gene is a major component of the synaptonemal complex and may bind DNA at scaffold attachment regions. The encoded protein requires synaptonemal complex protein 3, but not 1, for inclusion in the synaptonemal complex. [provided by RefSeq].
Aston, K.I., et al. Hum. Reprod. 25(6):1383-1397(2010)
Sugiyama, N., et al. Mol. Cell Proteomics 6(6):1103-1109(2007)
Deloukas, P., et al. Nature 414(6866):865-871(2001)
Schalk, J.A., et al. Mamm. Genome 10(6):642-644(1999)
Offenberg, H.H., et al. Nucleic Acids Res. 26(11):2572-2579(1998)
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