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SYCP2 Antibody (C-term)

Affinity Purified Rabbit Polyclonal Antibody (Pab)

     
  • WB - SYCP2 Antibody (C-term) AP18626b
    SYCP2 Antibody (C-term) (Cat. #AP18626b) western blot analysis in NCI-H292 cell line lysates (35ug/lane).This demonstrates the SYCP2 antibody detected the SYCP2 protein (arrow).
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Product Information
Application
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • E=ELISA
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
WB, E
Primary Accession Q9BX26
Other Accession NP_055073.2
Reactivity Human
Host Rabbit
Clonality Polyclonal
Isotype Rabbit IgG
Calculated MW 175639 Da
Antigen Region 1345-1372 aa
Additional Information
Gene ID 10388
Other Names Synaptonemal complex protein 2, SCP-2, Synaptonemal complex lateral element protein, hsSCP2, SYCP2, SCP2
Target/Specificity This SYCP2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 1345-1372 amino acids from the C-terminal region of human SYCP2.
Dilution WB~~1:1000
Format Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.
StorageMaintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
PrecautionsSYCP2 Antibody (C-term) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name SYCP2
Synonyms SCP2
Function Major component of the axial/lateral elements of synaptonemal complexes (SCS) during meiotic prophase. Plays a role in the assembly of synaptonemal complexes. Required for normal meiotic chromosome synapsis during oocyte and spermatocyte development and for normal male and female fertility. Required for insertion of SYCP3 into synaptonemal complexes. May be involved in the organization of chromatin by temporarily binding to DNA scaffold attachment regions. Requires SYCP3, but not SYCP1, in order to be incorporated into the axial/lateral elements.
Cellular Location Nucleus {ECO:0000250|UniProtKB:Q9CUU3}. Chromosome {ECO:0000250|UniProtKB:Q9CUU3}. Note=In axial/lateral elements of the tripartite segments of synaptonemal complexes {ECO:0000250|UniProtKB:Q9CUU3}
Research Areas
Citations (0)
citation

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Background

The synaptonemal complex is a proteinaceous structure that links homologous chromosomes during the prophase of meiosis. The protein encoded by this gene is a major component of the synaptonemal complex and may bind DNA at scaffold attachment regions. The encoded protein requires synaptonemal complex protein 3, but not 1, for inclusion in the synaptonemal complex. [provided by RefSeq].

References

Aston, K.I., et al. Hum. Reprod. 25(6):1383-1397(2010)
Sugiyama, N., et al. Mol. Cell Proteomics 6(6):1103-1109(2007)
Deloukas, P., et al. Nature 414(6866):865-871(2001)
Schalk, J.A., et al. Mamm. Genome 10(6):642-644(1999)
Offenberg, H.H., et al. Nucleic Acids Res. 26(11):2572-2579(1998)

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$ 365.00
$ 140.00
Cat# AP18626b
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