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AMOT Antibody (N-term)Peptide Affinity Purified Rabbit Polyclonal Antibody (Pab)
| Country | United States
Ordering Information
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| Catalog # | Size | Availability | Price | |
| AP18634a | 0.1 mg 400 ul | In Stock | $ 255.00 | DISCONTINED INQUIRE CLICK INQUIRE Add to cart |
| AP18634a-ev20 | 20 ug 100 ul | In Stock | $ 95.00 | DISCONTINED INQUIRE CLICK INQUIRE Add to cart |
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AMOT Antibody (N-term) - Product info | |
| Application | WB
|
| Primary Accession | Q4VCS5 |
| Other Accession | NP_001106962.1 |
| Reactivity | Human |
| Concentration | 0.25 mg/ml |
| Isotype | Rabbit Ig |
| Calculated MW | 118085 Da |
AMOT Antibody (N-term) - Additional info | |
| Gene ID 154796 | |
| Other Names AMOT; KIAA1071; Angiomotin | |
| Target/Specificity This AMOT antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 238-267 amino acids from the N-terminal region of human AMOT. | |
| Dilution WB~~1:100~500WB~~1:1000 | |
| Format Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification. | |
| Storage Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. | |
| Precautions AMOT Antibody (N-term) is for research use only and not for use in diagnostic or therapeutic procedures. | |
AMOT Antibody (N-term) - Protein Information | |
| Name AMOT | |
| Synonyms KIAA1071 | |
| Function Plays a central role in tight junction maintenance via the complex formed with ARHGAP17, which acts by regulating the uptake of polarity proteins at tight junctions. Appears to regulate endothelial cell migration and tube formation. May also play a role in the assembly of endothelial cell-cell junctions | |
| Cellular Location Cell junction, tight junction. Note=Localized on the cell surface. May act as a transmembrane protein | |
| Tissue Location Expressed in placenta and skeletal muscle. Found in the endothelial cells of capillaries as well as larger vessels of the placenta | |
AMOT Antibody (N-term) - Related products
AP18634a: AMOT Antibody (N-term)
AP19246c: AMOT Antibody (Center S787)
AP19247c: AMOT Antibody (Center S305)
AMOT Antibody (N-term) - Application data
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AMOT Antibody (N-term) (Cat. #AP18634a) western blot analysis in CEM cell line lysates (35ug/lane).This demonstrates the AMOT antibody detected the AMOT protein (arrow).
AMOT Antibody (N-term) - Research Areas
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BACKGROUND
This gene belongs to the motin family of angiostatin binding proteins characterized by conserved coiled-coil domains and C-terminal PDZ binding motifs. The encoded protein is expressed predominantly in endothelial cells of capillaries as well as larger vessels of the placenta where it may mediate the inhibitory effect of angiostatin on tube formation and the migration of endothelial cells toward growth factors during the formation of new blood vessels. Alternative splicing results in multiple transcript variants encoding different isoforms.
REFERENCES
Bailey, S.D., et al. Diabetes Care 33(10):2250-2253(2010) Heller, B., et al. J. Biol. Chem. 285(16):12308-12320(2010) Talmud, P.J., et al. Am. J. Hum. Genet. 85(5):628-642(2009) Gagne, V., et al. Cell Motil. Cytoskeleton 66(9):754-768(2009) Zheng, Y., et al. Circ. Res. 105(3):260-270(2009)
