|Application ||WB, E|
|Calculated MW||44085 Da|
|Antigen Region||369-398 aa|
|Other Names||Lymphocyte transmembrane adapter 1, Linker for activation of X cells, Membrane-associated adapter protein LAX, LAX1, LAX|
|Target/Specificity||This LAX1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 369-398 amino acids from the C-terminal region of human LAX1.|
|Format||Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||LAX1 Antibody (C-term) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Negatively regulates TCR (T-cell antigen receptor)- mediated signaling in T-cells and BCR (B-cell antigen receptor)- mediated signaling in B-cells.|
|Cellular Location||Cell membrane; Single-pass type III membrane protein|
|Tissue Location||Expressed in spleen, thymus, and peripheral blood leukocytes. Expressed in several B-, T-, NK and monocyte cell lines.|
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Provided below are standard protocols that you may find useful for product applications.
LAX1 negatively regulates TCR (T-cell antigen receptor)-mediated signaling in T-cells and BCR (B-cell antigen receptor)-mediated signaling in B-cells.
Ehret, G.B., et al. Eur. J. Hum. Genet. 17(12):1650-1657(2009)
Shapiro, M.J., et al. J. Immunol. 181(10):7055-7061(2008)
Zhu, M., et al. J. Immunol. 174(9):5612-5619(2005)
Zhu, M., et al. J. Biol. Chem. 277(48):46151-46158(2002)
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