LAX1 Antibody (C-term)
Affinity Purified Rabbit Polyclonal Antibody (Pab)
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application
| WB, E |
---|---|
Primary Accession | Q8IWV1 |
Other Accession | NP_001129662.1 |
Reactivity | Human |
Host | Rabbit |
Clonality | Polyclonal |
Isotype | Rabbit IgG |
Calculated MW | 44085 Da |
Antigen Region | 369-398 aa |
Gene ID | 54900 |
---|---|
Other Names | Lymphocyte transmembrane adapter 1, Linker for activation of X cells, Membrane-associated adapter protein LAX, LAX1, LAX |
Target/Specificity | This LAX1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 369-398 amino acids from the C-terminal region of human LAX1. |
Dilution | WB~~1:1000 |
Format | Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification. |
Storage | Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. |
Precautions | LAX1 Antibody (C-term) is for research use only and not for use in diagnostic or therapeutic procedures. |
Name | LAX1 |
---|---|
Synonyms | LAX |
Function | Negatively regulates TCR (T-cell antigen receptor)-mediated signaling in T-cells and BCR (B-cell antigen receptor)-mediated signaling in B-cells. |
Cellular Location | Cell membrane; Single-pass type III membrane protein |
Tissue Location | Expressed in spleen, thymus, and peripheral blood leukocytes. Expressed in several B-, T-, NK and monocyte cell lines |
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Provided below are standard protocols that you may find useful for product applications.
Background
LAX1 negatively regulates TCR (T-cell antigen receptor)-mediated signaling in T-cells and BCR (B-cell antigen receptor)-mediated signaling in B-cells.
References
Ehret, G.B., et al. Eur. J. Hum. Genet. 17(12):1650-1657(2009)
Shapiro, M.J., et al. J. Immunol. 181(10):7055-7061(2008)
Zhu, M., et al. J. Immunol. 174(9):5612-5619(2005)
Zhu, M., et al. J. Biol. Chem. 277(48):46151-46158(2002)
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