|Application ||WB, E|
|Calculated MW||44085 Da|
|Antigen Region||369-398 aa|
|Other Names||Lymphocyte transmembrane adapter 1, Linker for activation of X cells, Membrane-associated adapter protein LAX, LAX1, LAX|
|Target/Specificity||This LAX1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 369-398 amino acids from the C-terminal region of human LAX1.|
|Format||Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||LAX1 Antibody (C-term) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Negatively regulates TCR (T-cell antigen receptor)- mediated signaling in T-cells and BCR (B-cell antigen receptor)- mediated signaling in B-cells.|
|Cellular Location||Cell membrane; Single-pass type III membrane protein|
|Tissue Location||Expressed in spleen, thymus, and peripheral blood leukocytes. Expressed in several B-, T-, NK and monocyte cell lines.|
Thousands of laboratories across the world have published research that depended on the performance of antibodies from Abgent to advance their research. Check out links to articles that cite our products in major peer-reviewed journals, organized by research category.
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Provided below are standard protocols that you may find useful for product applications.
LAX1 negatively regulates TCR (T-cell antigen receptor)-mediated signaling in T-cells and BCR (B-cell antigen receptor)-mediated signaling in B-cells.
Ehret, G.B., et al. Eur. J. Hum. Genet. 17(12):1650-1657(2009)
Shapiro, M.J., et al. J. Immunol. 181(10):7055-7061(2008)
Zhu, M., et al. J. Immunol. 174(9):5612-5619(2005)
Zhu, M., et al. J. Biol. Chem. 277(48):46151-46158(2002)
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