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SAP30L Antibody (Center)

Affinity Purified Rabbit Polyclonal Antibody (Pab)

     
  • WB - SAP30L Antibody (Center) AP18649c
    SAP30L Antibody (Center) (Cat. #AP18649c) western blot analysis in MCF-7 cell line lysates (35ug/lane).This demonstrates the SAP30L antibody detected the SAP30L protein (arrow).
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Product Information
Application
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • E=ELISA
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
WB, E
Primary Accession Q9HAJ7
Other Accession Q5SQF8, NP_001124534.1
Reactivity Human
Predicted Mouse
Host Rabbit
Clonality Polyclonal
Isotype Rabbit IgG
Calculated MW 20877 Da
Antigen Region 106-134 aa
Additional Information
Gene ID 79685
Other Names Histone deacetylase complex subunit SAP30L, HCV non-structural protein 4A-transactivated protein 2, Sin3 corepressor complex subunit SAP30L, Sin3-associated protein p30-like, SAP30L, NS4ATP2
Target/Specificity This SAP30L antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 106-134 amino acids from the Central region of human SAP30L.
Dilution WB~~1:1000
Format Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.
StorageMaintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
PrecautionsSAP30L Antibody (Center) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name SAP30L
Synonyms NS4ATP2
Function [Isoform 1]: Functions as a transcription repressor, probably via its interaction with histone deacetylase complexes (PubMed:16820529, PubMed:18070604). Involved in the functional recruitment of the class 1 Sin3-histone deacetylase complex (HDAC) to the nucleolus (PubMed:16820529). Binds DNA, apparently without sequence-specificity, and bends bound double-stranded DNA (PubMed:19015240). Binds phosphoinositol phosphates (phosphoinositol 3- phosphate, phosphoinositol 4-phosphate and phosphoinositol 5-phosphate) via the same basic sequence motif that mediates DNA binding and nuclear import (PubMed:19015240, PubMed:26609676).
Cellular Location [Isoform 1]: Nucleus, nucleolus [Isoform 3]: Nucleus, nucleolus
Tissue Location Detected in brain and ovary, and at lower levels in heart, small intestine, lung, kidney, skeletal muscle, stomach and spleen (at protein level) (PubMed:18070604). Ubiquitous; expressed in all tissues tested with highest levels in testis (PubMed:14680513)
Research Areas
Citations (0)
citation

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Background

SAP30L is involved in the functional recruitment of the class 1 Sin3-histone deacetylase complex (HDAC) to the nucleolus.

References

Silva, L.K., et al. Eur. J. Hum. Genet. (2010) In press :
Viiri, K.M., et al. Mol. Cell. Biol. 29(2):342-356(2009)
Korkeamaki, H., et al. FEBS Lett. 582(2):379-384(2008)
Assmann, E.M., et al. J. Biol. Chem. 281(15):9869-9881(2006)
Beausoleil, S.A., et al. Proc. Natl. Acad. Sci. U.S.A. 101(33):12130-12135(2004)

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$ 182.50
$ 70.00
Cat# AP18649c
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