|Application ||WB, E|
|Other Accession||Q9D662, Q3SZN2, NP_001166216.1|
|Calculated MW||86479 Da|
|Antigen Region||655-684 aa|
|Other Names||Protein transport protein Sec23B, SEC23-related protein B, SEC23B|
|Target/Specificity||This SEC23B antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 655-684 amino acids from the C-terminal region of human SEC23B.|
|Format||Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||SEC23B Antibody (C-term) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Component of the COPII coat, that covers ER-derived vesicles involved in transport from the endoplasmic reticulum to the Golgi apparatus. COPII acts in the cytoplasm to promote the transport of secretory, plasma membrane, and vacuolar proteins from the endoplasmic reticulum to the Golgi complex (By similarity).|
|Cellular Location||Golgi apparatus membrane. Endoplasmic reticulum membrane. Endoplasmic reticulum-Golgi intermediate compartment membrane|
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Provided below are standard protocols that you may find useful for product applications.
The protein encoded by this gene is a member of the SEC23 subfamily of the SEC23/SEC24 family, which is involved in vesicle trafficking. The encoded protein has similarity to yeast Sec23p component of COPII. COPII is the coat protein complex responsible for vesicle budding from the ER. The function of this gene product has been implicated in cargo selection and concentration. Multiple alternatively spliced transcript variants have been identified in this gene.
Rose, J.E., et al. Mol. Med. 16 (7-8), 247-253 (2010) :
Fermo, E., et al. Blood Cells Mol. Dis. 45(1):20-22(2010)
Bianchi, P., et al. Hum. Mutat. 30(9):1292-1298(2009)
Schwarz, K., et al. Nat. Genet. 41(8):936-940(2009)
Oh, J.H., et al. Mamm. Genome 16(12):942-954(2005)
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