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SEC23B Antibody (C-term)

Affinity Purified Rabbit Polyclonal Antibody (Pab)

     
  • WB - SEC23B Antibody (C-term) AP18650b
    SEC23B Antibody (C-term) (Cat. #AP18650b) western blot analysis in WiDr cell line lysates (35ug/lane).This demonstrates the SEC23B antibody detected the SEC23B protein (arrow).
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Product Information
Application
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • E=ELISA
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
WB, E
Primary Accession Q15437
Other Accession Q9D662, Q3SZN2, NP_001166216.1
Reactivity Human
Predicted Bovine, Mouse
Host Rabbit
Clonality Polyclonal
Isotype Rabbit IgG
Calculated MW 86479 Da
Antigen Region 655-684 aa
Additional Information
Gene ID 10483
Other Names Protein transport protein Sec23B, SEC23-related protein B, SEC23B
Target/Specificity This SEC23B antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 655-684 amino acids from the C-terminal region of human SEC23B.
Dilution WB~~1:1000
Format Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.
StorageMaintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
PrecautionsSEC23B Antibody (C-term) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name SEC23B (HGNC:10702)
Function Component of the coat protein complex II (COPII) which promotes the formation of transport vesicles from the endoplasmic reticulum (ER). The coat has two main functions, the physical deformation of the endoplasmic reticulum membrane into vesicles and the selection of cargo molecules for their transport to the Golgi complex.
Cellular Location Cytoplasmic vesicle, COPII-coated vesicle membrane {ECO:0000250|UniProtKB:Q15436}; Peripheral membrane protein {ECO:0000250|UniProtKB:Q15436}; Cytoplasmic side {ECO:0000250|UniProtKB:Q15436}. Endoplasmic reticulum membrane; Peripheral membrane protein {ECO:0000250|UniProtKB:Q15436}; Cytoplasmic side {ECO:0000250|UniProtKB:Q15436}. Cytoplasm, cytosol {ECO:0000250|UniProtKB:Q15436}
Tissue Location Ubiquitously expressed.
Research Areas
Citations (0)
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Background

The protein encoded by this gene is a member of the SEC23 subfamily of the SEC23/SEC24 family, which is involved in vesicle trafficking. The encoded protein has similarity to yeast Sec23p component of COPII. COPII is the coat protein complex responsible for vesicle budding from the ER. The function of this gene product has been implicated in cargo selection and concentration. Multiple alternatively spliced transcript variants have been identified in this gene.

References

Rose, J.E., et al. Mol. Med. 16 (7-8), 247-253 (2010) :
Fermo, E., et al. Blood Cells Mol. Dis. 45(1):20-22(2010)
Bianchi, P., et al. Hum. Mutat. 30(9):1292-1298(2009)
Schwarz, K., et al. Nat. Genet. 41(8):936-940(2009)
Oh, J.H., et al. Mamm. Genome 16(12):942-954(2005)

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$ 182.50
$ 70.00
Cat# AP18650b
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