|Application ||WB, E|
|Other Accession||Q9R1T4, Q3SZN0, NP_055944.2|
|Calculated MW||49717 Da|
|Antigen Region||400-426 aa|
|Other Names||Septin-6, SEPT6, KIAA0128, SEP2|
|Target/Specificity||This SEPT6 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 400-426 amino acids from the C-terminal region of human SEPT6.|
|Format||Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||SEPT6 Antibody (C-term) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Filament-forming cytoskeletal GTPase. Required for normal organization of the actin cytoskeleton. Involved in cytokinesis. May play a role in HCV RNA replication.|
|Cellular Location||Cytoplasm. Cytoplasm, cytoskeleton, spindle Chromosome, centromere, kinetochore Cleavage furrow. Midbody. Note=In metaphase cells, localized within the microtubule spindle. At the metaphase plate, in close apposition to the kinetochores of the congressed chromosomes. In cells undergoing cytokinesis, localized to the midbody, the ingressing cleavage furrow, and the central spindle|
|Tissue Location||Widely expressed.|
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Provided below are standard protocols that you may find useful for product applications.
This gene is a member of the septin family of GTPases. Members of this family are required for cytokinesis. One version of pediatric acute myeloid leukemia is the result of a reciprocal translocation between chromosomes 11 and X, with the breakpoint associated with the genes encoding the mixed-lineage leukemia and septin 2 proteins. This gene encodes four transcript variants encoding three distinct isoforms. An additional transcript variant has been identified, but its biological validity has not been determined.
Ding, X., et al. J. Biochem. Mol. Biol. 40(6):973-978(2007)
Sirajuddin, M., et al. Nature 449(7160):311-315(2007)
Kremer, B.E., et al. Cell 130(5):837-850(2007)
Matsuoka, S., et al. Science 316(5828):1160-1166(2007)
Kim, C.S., et al. J. Virol. 81(8):3852-3865(2007)
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