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GTF3A Antibody (C-term)
Affinity Purified Rabbit Polyclonal Antibody (Pab)
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application 
| WB, E |
|---|---|
| Primary Accession | Q92664 |
| Other Accession | NP_002088.2 |
| Reactivity | Human |
| Host | Rabbit |
| Clonality | Polyclonal |
| Isotype | Rabbit IgG |
| Calculated MW | 41515 Da |
| Antigen Region | 308-334 aa |
| Gene ID | 2971 |
|---|---|
| Other Names | Transcription factor IIIA, TFIIIA, GTF3A |
| Target/Specificity | This GTF3A antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 308-334 amino acids from the C-terminal region of human GTF3A. |
| Dilution | WB~~1:1000 |
| Format | Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification. |
| Storage | Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. |
| Precautions | GTF3A Antibody (C-term) is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | GTF3A |
|---|---|
| Function | Involved in ribosomal large subunit biogenesis. Binds the approximately 50 base pairs internal control region (ICR) of 5S ribosomal RNA genes. It is required for their RNA polymerase III- dependent transcription and may also maintain the transcription of other genes (PubMed:24120868). Also binds the transcribed 5S RNA's (By similarity). |
| Cellular Location | Nucleus. |
| Tissue Location | Ubiquitous. |
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Provided below are standard protocols that you may find useful for product applications.
Background
The product of this gene is a zinc finger protein with nine Cis[2]-His[2] zinc finger domains. It functions as an RNA polymerase III transcription factor to induce transcription of the 5S rRNA genes. The protein binds to a 50 bp internal promoter in the 5S genes called the internal control region (ICR), and nucleates formation of a stable preinitiation complex. This complex recruits the TFIIIC and TFIIIB transcription factors and RNA polymerase III to form the complete transcription complex. The protein is thought to be translated using a non-AUG translation initiation site in mammals based on sequence analysis, protein homology, and the size of the purified protein. [provided by RefSeq].
References
Wu, C., et al. Proteomics 7(11):1775-1785(2007)
Newton-Cheh, C., et al. BMC Med. Genet. 8 SUPPL 1, S7 (2007) :
Weser, S., et al. Nucleic Acids Res. 31(9):2408-2416(2003)
Hanas, J.S., et al. Gene 282 (1-2), 43-52 (2002) :
Moreland, R.J., et al. Nucleic Acids Res. 28(9):1986-1993(2000)
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