|Application ||WB, E|
|Calculated MW||41515 Da|
|Antigen Region||308-334 aa|
|Other Names||Transcription factor IIIA, TFIIIA, GTF3A|
|Target/Specificity||This GTF3A antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 308-334 amino acids from the C-terminal region of human GTF3A.|
|Format||Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||GTF3A Antibody (C-term) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Interacts with the internal control region (ICR) of approximately 50 bases within the 5S RNA genes, is required for correct transcription of these genes by RNA polymerase III. Also binds the transcribed 5S RNA's. May initiate transcription of the 5S ribosomal RNA gene and maintain the stability of transcription of other genes.|
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Provided below are standard protocols that you may find useful for product applications.
The product of this gene is a zinc finger protein with nine Cis-His zinc finger domains. It functions as an RNA polymerase III transcription factor to induce transcription of the 5S rRNA genes. The protein binds to a 50 bp internal promoter in the 5S genes called the internal control region (ICR), and nucleates formation of a stable preinitiation complex. This complex recruits the TFIIIC and TFIIIB transcription factors and RNA polymerase III to form the complete transcription complex. The protein is thought to be translated using a non-AUG translation initiation site in mammals based on sequence analysis, protein homology, and the size of the purified protein. [provided by RefSeq].
Wu, C., et al. Proteomics 7(11):1775-1785(2007)
Newton-Cheh, C., et al. BMC Med. Genet. 8 SUPPL 1, S7 (2007) :
Weser, S., et al. Nucleic Acids Res. 31(9):2408-2416(2003)
Hanas, J.S., et al. Gene 282 (1-2), 43-52 (2002) :
Moreland, R.J., et al. Nucleic Acids Res. 28(9):1986-1993(2000)
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