|Application ||WB, E|
|Calculated MW||32679 Da|
|Antigen Region||215-241 aa|
|Other Names||Trem-like transcript 1 protein, TLT-1, Triggering receptor expressed on myeloid cells-like protein 1, TREML1, TLT1|
|Target/Specificity||This TREML1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 215-241 amino acids from the C-terminal region of human TREML1.|
|Format||Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||TREML1 Antibody (C-term) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Cell surface receptor that may play a role in the innate and adaptive immune response.|
|Cellular Location||Cell membrane; Single-pass type I membrane protein Cytoplasm. Note=Sequestered in cytoplasmic vesicles in resting platelets (PubMed:15100151) Transported to the cell surface after stimulation by thrombin (PubMed:15100151). Soluble fragments can be released into the serum by proteolysis (PubMed:16505478)|
|Tissue Location||Detected in platelets, monocytic leukemia and in T-cell leukemia.|
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Provided below are standard protocols that you may find useful for product applications.
TREML1 is located in a gene cluster on chromosome 6 with the single Ig variable (IgV) domain activating receptors TREM1 (MIM 605085) and TREM2 (MIM 605086), but it has distinct structural and functional properties. TREML1 enhances calcium signaling in an SHP2 (PTPN11; MIM 176876)-dependent manner (Allcock et al., 2003 [PubMed 12645956]; Barrow et al., 2004 [PubMed 15128762]).[supplied by OMIM].
Morales, J., et al. Blood Coagul. Fibrinolysis 21(3):229-236(2010)
Washington, A.V., et al. J. Clin. Invest. 119(6):1489-1501(2009)
Ford, J.W., et al. Curr. Opin. Immunol. 21(1):38-46(2009)
Nurden, A.T., et al. Thromb. Haemost. 100(1):45-51(2008)
Giomarelli, B., et al. Thromb. Haemost. 97(6):955-963(2007)
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