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>   home   >   Products   >   Primary Antibodies   >   Immunology   >   Mouse Il17ra Antibody (C-term)   

Mouse Il17ra Antibody (C-term)

Peptide Affinity Purified Rabbit Polyclonal Antibody (Pab)

     
  • WB - Mouse Il17ra Antibody (C-term) AP18687b
    Mouse Il17ra Antibody (C-term) (Cat. #AP18687b) western blot analysis in mouse NIH-3T3 cell line lysates (35ug/lane).This demonstrates the Mouse Il17ra antibody detected the Mouse Il17ra protein (arrow).
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Product Information
Application
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • E=ELISA
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
WB, E
Primary Accession Q60943
Other Accession NP_032385.1
Reactivity Mouse
Host Rabbit
Clonality Polyclonal
Isotype Rabbit Ig
Calculated MW 97808 Da
Antigen Region 721-747 aa
Additional Information
Gene ID 16172
Other Names Interleukin-17 receptor A, IL-17 receptor A, IL-17RA, CD217, Il17ra, Il17r
Target/Specificity This Mouse Il17ra antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 721-747 amino acids from the C-terminal region of mouse Il17ra.
Dilution WB~~1:1000
Format Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.
StorageMaintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
PrecautionsMouse Il17ra Antibody (C-term) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name Il17ra
Synonyms Il17r
Function Receptor for IL17A (PubMed:17911633, PubMed:20554964, PubMed:8777726). Receptor for IL17F (PubMed:17911633, PubMed:20554964). Binds to IL17A with higher affinity than to IL17F (PubMed:17911633). Binds IL17A and IL17F homodimers as part of a heterodimeric complex with IL17RC (By similarity). Also binds heterodimers formed by IL17A and IL17F as part of a heterodimeric complex with IL17RC (By similarity). Receptor for IL17C as part of a heterodimeric complex with IL17RE (PubMed:21993848, PubMed:21993849, PubMed:21982598). Activation of IL17RA leads to induction of expression of inflammatory chemokines and cytokines such as CXCL1, CXCL8/IL8 and IL6 (By similarity).
Cellular Location Cell membrane; Single-pass type I membrane protein
Tissue Location Widely expressed.
Research Areas
Citations (0)

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Background

Receptor for IL17A. Binds its ligand with low affinity, suggesting that additional components are involved in IL17A-induced signaling (By similarity).

References

Onishi, R.M., et al. J. Biol. Chem. 285(43):32751-32759(2010)
Guiton, R., et al. J. Infect. Dis. 202(3):427-435(2010)
Mitsdoerffer, M., et al. Proc. Natl. Acad. Sci. U.S.A. 107(32):14292-14297(2010)
Hill, G.R., et al. Blood 116(5):819-828(2010)
Wu, H.J., et al. Immunity 32(6):815-827(2010)

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Cat# AP18687b
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(40 western blots)
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