|Application ||WB, E|
|Calculated MW||97808 Da|
|Antigen Region||721-747 aa|
|Other Names||Interleukin-17 receptor A, IL-17 receptor A, IL-17RA, CD217, Il17ra, Il17r|
|Target/Specificity||This Mouse Il17ra antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 721-747 amino acids from the C-terminal region of mouse Il17ra.|
|Format||Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||Mouse Il17ra Antibody (C-term) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Receptor for IL17A (PubMed:17911633, PubMed:20554964, PubMed:8777726). Receptor for IL17F (PubMed:17911633, PubMed:20554964). Binds to IL17A with higher affinity than to IL17F (PubMed:17911633). Binds IL17A and IL17F homodimers as part of a heterodimeric complex with IL17RC (By similarity). Also binds heterodimers formed by IL17A and IL17F as part of a heterodimeric complex with IL17RC (By similarity). Receptor for IL17C as part of a heterodimeric complex with IL17RE (PubMed:21993848, PubMed:21993849, PubMed:21982598). Activation of IL17RA leads to induction of expression of inflammatory chemokines and cytokines such as CXCL1, CXCL8/IL8 and IL6 (By similarity).|
|Cellular Location||Cell membrane; Single-pass type I membrane protein|
|Tissue Location||Widely expressed.|
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Provided below are standard protocols that you may find useful for product applications.
Receptor for IL17A. Binds its ligand with low affinity, suggesting that additional components are involved in IL17A-induced signaling (By similarity).
Onishi, R.M., et al. J. Biol. Chem. 285(43):32751-32759(2010)
Guiton, R., et al. J. Infect. Dis. 202(3):427-435(2010)
Mitsdoerffer, M., et al. Proc. Natl. Acad. Sci. U.S.A. 107(32):14292-14297(2010)
Hill, G.R., et al. Blood 116(5):819-828(2010)
Wu, H.J., et al. Immunity 32(6):815-827(2010)
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