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>   home   >   Products   >   Primary Antibodies   >   Immunology   >   Mouse Il17ra Antibody (C-term)   

Mouse Il17ra Antibody (C-term)

Peptide Affinity Purified Rabbit Polyclonal Antibody (Pab)

     
  • WB - Mouse Il17ra Antibody (C-term) AP18687b
    Mouse Il17ra Antibody (C-term) (Cat. #AP18687b) western blot analysis in mouse NIH-3T3 cell line lysates (35ug/lane).This demonstrates the Mouse Il17ra antibody detected the Mouse Il17ra protein (arrow).
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Product Information
Application
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • E=ELISA
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
WB, E
Primary Accession Q60943
Other Accession NP_032385.1
Reactivity Mouse
Host Rabbit
Clonality Polyclonal
Isotype Rabbit IgG
Antigen Region 721-747 aa
Additional Information
Other Names Interleukin-17 receptor A, IL-17 receptor A, IL-17RA, CD217, Il17ra, Il17r
Target/Specificity This Mouse Il17ra antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 721-747 amino acids of mouse Il17ra.
Dilution WB~~1:1000
Format Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.
StorageMaintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
PrecautionsMouse Il17ra Antibody (C-term) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name Il17ra
Synonyms Il17r
Function Receptor for IL17A (PubMed:17911633, PubMed:20554964, PubMed:8777726). Receptor for IL17F (PubMed:17911633, PubMed:20554964). Binds to IL17A with higher affinity than to IL17F (PubMed:17911633). Binds IL17A and IL17F homodimers as part of a heterodimeric complex with IL17RC (By similarity). Also binds heterodimers formed by IL17A and IL17F as part of a heterodimeric complex with IL17RC (By similarity). Receptor for IL17C as part of a heterodimeric complex with IL17RE (PubMed:21993848, PubMed:21993849, PubMed:21982598). Activation of IL17RA leads to induction of expression of inflammatory chemokines and cytokines such as CXCL1, CXCL8/IL8 and IL6 (By similarity).
Cellular Location Cell membrane; Single-pass type I membrane protein
Tissue Location Widely expressed. EMBL; U31993; AAC52357.1; -; mRNA CCDS; CCDS20482.1; - RefSeq; NP_032385.1; NM_008359.2 UniGene; Mm.4481; - ProteinModelPortal; Q60943; - SMR; Q60943; - BioGrid; 200620; 5 IntAct; Q60943; 4 STRING; 10090.ENSMUSP00000002976; - iPTMnet; Q60943; - PhosphoSitePlus; Q60943; - EPD; Q60943; - MaxQB; Q60943; - PaxDb; Q60943; - PeptideAtlas; Q60943; - PRIDE; Q60943; - DNASU; 16172; - Ensembl; ENSMUST00000002976; ENSMUSP00000002976; ENSMUSG00000002897 GeneID; 16172; - KEGG; mmu:16172; - UCSC; uc009dnj.2; mouse CTD; 23765; - MGI; MGI:107399; Il17ra eggNOG; ENOG410IH6C; Eukaryota eggNOG; ENOG4111HRA; LUCA GeneTree; ENSGT00880000137935; - HOGENOM; HOG000015327; - HOVERGEN; HBG081775; - InParanoid; Q60943; - KO; K05164; - OMA; PDLFNIT; - OrthoDB; EOG091G01XZ; - PhylomeDB; Q60943; - TreeFam; TF329644; - Reactome; R-MMU-448424; Interleukin-17 signaling ChiTaRS; Il17ra; mouse PRO; PR:Q60943; - Proteomes; UP000000589; Chromosome 6 Bgee; ENSMUSG00000002897; - CleanEx; MM_IL17RA; - Genevisible; Q60943; MM GO; GO:0005887; C:integral component of plasma membrane; IBA:GO_Central GO; GO:0005886; C:plasma membrane; IDA:MGI GO; GO:0030368; F:interleukin-17 receptor activity; IBA:GO_Central GO; GO:0005102; F:signaling receptor binding; IPI:UniProtKB GO; GO:0071345; P:cellular response to cytokine stimulus; ISO:MGI GO; GO:0050832; P:defense response to fungus; IMP:UniProtKB GO; GO:0072537; P:fibroblast activation; ISO:MGI GO; GO:0071621; P:granulocyte chemotaxis; IMP:UniProtKB GO; GO:1900017; P:positive regulation of cytokine production involved in inflammatory response; IGI:MGI GO; GO:0050729; P:positive regulation of inflammatory response; IMP:MGI GO; GO:2000667; P:positive regulation of interleukin-13 secretion; IMP:MGI GO; GO:0032747; P:positive regulation of interleukin-23 production; ISO:MGI GO; GO:2000664; P:positive regulation of interleukin-5 secretion; IMP:MGI Gene3D; 2.60.40.2160; -; 1 InterPro; IPR032356; IL17R_fnIII_D1 InterPro; IPR038683; IL17RA/B_FnIII-like_1_sf InterPro; IPR013568; SEFIR_dom Pfam; PF16556; IL17R_fnIII_D1; 1 Pfam; PF08357; SEFIR; 1 PROSITE; PS51534; SEFIR; 1 1: Evidence at protein level; Cell membrane; Complete proteome; Disulfide bond; Glycoprotein; Membrane; Phosphoprotein; Receptor; Reference proteome; Signal; Transmembrane; Transmembrane helix SIGNAL 1 31 CHAIN 32 864 Interleukin-17 receptor A /FTId=PRO_0000011031 TOPO_DOM 32 322 Extracellular. TRANSMEM 323 343 Helical. TOPO_DOM 344 864 Cytoplasmic. DOMAIN 379 537 SEFIR. {ECO:0000255|PROSITE- ProRule:PRU00867} COMPBIAS 809 814 Poly-Glu MOD_RES 736 736 Phosphoserine CARBOHYD 54 54 N-linked (GlcNAc...) asparagine CARBOHYD 79 79 N-linked (GlcNAc...) asparagine CARBOHYD 206 206 N-linked (GlcNAc...) asparagine CARBOHYD 225 225 N-linked (GlcNAc...) asparagine CARBOHYD 242 242 N-linked (GlcNAc...) asparagine CARBOHYD 265 265 N-linked (GlcNAc...) asparagine CARBOHYD 308 308 N-linked (GlcNAc...) asparagine DISULFID 43 50 DISULFID 57 126 DISULFID 185 196 DISULFID 245 276 DISULFID 290 294 SEQUENCE 864 AA; 97808 MW; 343FD51AA687DA31 CRC64; MAIRRCWPRV VPGPALGWLL LLLNVLAPGR ASPRLLDFPA PVCAQEGLSC RVKNSTCLDD SWIHPKNLTP SSPKNIYINL SVSSTQHGEL VPVLHVEWTL QTDASILYLE GAELSVLQLN TNERLCVKFQ FLSMLQHHRK RWRFSFSHFV VDPGQEYEVT VHHLPKPIPD GDPNHKSKII FVPDCEDSKM KMTTSCVSSG SLWDPNITVE TLDTQHLRVD FTLWNESTPY QVLLESFSDS ENHSCFDVVK QIFAPRQEEF HQRANVTFTL SKFHWCCHHH VQVQPFFSSC LNDCLRHAVT VPCPVISNTT VPKPVADYIP LWVYGLITLI AILLVGSVIV LIICMTWRLS GADQEKHGDD SKINGILPVA DLTPPPLRPR KVWIVYSADH PLYVEVVLKF AQFLITACGT EVALDLLEEQ VISEVGVMTW VSRQKQEMVE SNSKIIILCS RGTQAKWKAI LGWAEPAVQL RCDHWKPAGD LFTAAMNMIL PDFKRPACFG TYVVCYFSGI CSERDVPDLF NITSRYPLMD RFEEVYFRIQ DLEMFEPGRM HHVRELTGDN YLQSPSGRQL KEAVLRFQEW QTQCPDWFER ENLCLADGQD LPSLDEEVFE DPLLPPGGGI VKQQPLVREL PSDGCLVVDV CVSEEESRMA KLDPQLWPQR ELVAHTLQSM VLPAEQVPAA HVVEPLHLPD GSGAAAQLPM TEDSEACPLL GVQRNSILCL PVDSDDLPLC STPMMSPDHL QGDAREQLES LMLSVLQQSL SGQPLESWPR PEVVLEGCTP SEEEQRQSVQ SDQGYISRSS PQPPEWLTEE EELELGEPVE SLSPEELRSL RKLQRQLFFW ELEKNPGWNS LEPRRPTPEE QNPS
Research Areas
Citations (0)

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Background

Receptor for IL17A. Binds its ligand with low affinity, suggesting that additional components are involved in IL17A-induced signaling (By similarity).

References

Onishi, R.M., et al. J. Biol. Chem. 285(43):32751-32759(2010)
Guiton, R., et al. J. Infect. Dis. 202(3):427-435(2010)
Mitsdoerffer, M., et al. Proc. Natl. Acad. Sci. U.S.A. 107(32):14292-14297(2010)
Hill, G.R., et al. Blood 116(5):819-828(2010)
Wu, H.J., et al. Immunity 32(6):815-827(2010)

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Discontinued
Cat# AP18687b
Size:
(40 western blots)
Alternative Products:

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