Mouse Parva Antibody (N-term)
Affinity Purified Rabbit Polyclonal Antibody (Pab)
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application
| WB, E |
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Primary Accession | Q9EPC1 |
Other Accession | Q9HB97, NP_065631.3 |
Reactivity | Mouse |
Predicted | Rat |
Host | Rabbit |
Clonality | Polyclonal |
Isotype | Rabbit IgG |
Calculated MW | 42330 Da |
Antigen Region | 66-93 aa |
Gene ID | 57342 |
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Other Names | Alpha-parvin, Actopaxin, Parva, Actp |
Target/Specificity | This Mouse Parva antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 66-93 amino acids from the N-terminal region of mouse Parva. |
Dilution | WB~~1:1000 |
Format | Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification. |
Storage | Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. |
Precautions | Mouse Parva Antibody (N-term) is for research use only and not for use in diagnostic or therapeutic procedures. |
Name | Parva |
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Synonyms | Actp |
Function | Plays a role in sarcomere organization and in smooth muscle cell contraction. Required for normal development of the embryonic cardiovascular system, and for normal septation of the heart outflow tract. Plays a role in sprouting angiogenesis and is required for normal adhesion of vascular smooth muscle cells to endothelial cells during blood vessel development. Plays a role in the reorganization of the actin cytoskeleton, formation of lamellipodia and ciliogenesis. Plays a role in the establishment of cell polarity, cell adhesion, cell spreading, and directed cell migration. |
Cellular Location | Cell junction, focal adhesion. Cell membrane; Peripheral membrane protein; Cytoplasmic side. Cytoplasm, cytoskeleton Cytoplasm, myofibril, sarcomere, Z line. Note=Constituent of focal adhesions |
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Provided below are standard protocols that you may find useful for product applications.
Background
Parva probably plays a role in the regulation of cell adhesion and cytoskeleton organization.
References
Montanez, E., et al. EMBO J. 28(20):3132-3144(2009)
Lange, A., et al. Nature 461(7266):1002-1006(2009)
Stanchi, F., et al. J. Cell. Sci. 122 (PT 11), 1800-1811 (2009) :
Pereira, J.A., et al. J. Cell Biol. 185(1):147-161(2009)
Falco, G., et al. Reprod. Biomed. Online 13(3):394-403(2006)
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