|Application ||WB, E|
|Other Accession||Q8BKK4, NP_001074014.1|
|Calculated MW||12346 Da|
|Antigen Region||50-76 aa|
|Other Names||Protein phosphatase 1 regulatory subunit 1C, Inhibitor-5 of protein phosphatase 1, IPP5, PPP1R1C|
|Target/Specificity||This PPP1R1C antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 50-76 amino acids from the N-terminal region of human PPP1R1C.|
|Format||Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||PPP1R1C Antibody (N-term) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Inhibitor of protein-phosphatase 1. Promotes cell growth and cell cycle progress at the G1/S transition. May increase cell susceptibility to TNF-induced apoptosis.|
|Tissue Location||Expressed in heart, skeletal muscle, liver and testis (at protein level)|
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Provided below are standard protocols that you may find useful for product applications.
Protein phosphatase-1 (PP1) is a major serine/threonine phosphatase that regulates a variety of cellular functions. PP1 consists of a catalytic subunit (see PPP1CA; MIM 176875) and regulatory subunits that determine the subcellular localization of PP1 or regulate its function. PPP1R1C belongs to a group of PP1 inhibitory subunits that are themselves regulated by phosphorylation (Wang et al., 2008 [PubMed 18310074]).[supplied by OMIM].
Dick, D.M., et al. Am. J. Med. Genet. B Neuropsychiatr. Genet. (2010) In press :
Rose, J. Phd, et al. Mol. Med. (2010) In press :
Zeng, Q., et al. Biotechnol. Appl. Biochem. 54(4):231-238(2009)
Wang, X., et al. J. Biol. Chem. 283(18):12076-12084(2008)
Ceulemans, H., et al. Bioessays 24(4):371-381(2002)
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