|Application ||WB, E|
|Calculated MW||32787 Da|
|Antigen Region||251-280 aa|
|Other Names||Protein CLN8, CLN8, C8orf61|
|Target/Specificity||This CLN8 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 251-280 amino acids from the C-terminal region of human CLN8.|
|Format||Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||CLN8 Antibody (C-term) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Could play a role in cell proliferation during neuronal differentiation and in protection against cell death.|
|Cellular Location||Endoplasmic reticulum membrane; Multi-pass membrane protein. Endoplasmic reticulum-Golgi intermediate compartment membrane; Multi-pass membrane protein Endoplasmic reticulum|
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Provided below are standard protocols that you may find useful for product applications.
This gene encodes a transmembrane protein belonging to a family of proteins containing TLC domains, which are postulated to function in lipid synthesis, transport, or sensing. The protein localizes to the endoplasmic reticulum (ER), and may recycle between the ER and ER-Golgi intermediate compartment. Mutations in this gene are associated with progressive epilepsy with mental retardation (EMPR), which is a subtype of neuronal ceroid lipofuscinoses (NCL). Patients with mutations in this gene have altered levels of sphingolipid and phospholipids in the brain.
Reinhardt, K., et al. Clin. Genet. 77(1):79-85(2010)
Vantaggiato, C., et al. Hum. Mutat. 30(7):1104-1116(2009)
Kousi, M., et al. Brain 132 (PT 3), 810-819 (2009) :
Striano, P., et al. Epilepsy Behav 10(1):187-191(2007)
Hermansson, M., et al. J. Neurochem. 95(3):609-617(2005)
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