|Application ||WB, E|
|Other Accession||Q78JE5, NP_036302.1|
|Calculated MW||44508 Da|
|Antigen Region||320-347 aa|
|Other Names||F-box only protein 22, F-box protein FBX22p44, FBXO22, FBX22|
|Target/Specificity||This FBXO22 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 320-347 amino acids from the C-terminal region of human FBXO22.|
|Precautions||FBXO22 Antibody (C-term) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Substrate-recognition component of the SCF (SKP1-CUL1-F- box protein)-type E3 ubiquitin ligase complex. Promotes the proteasome-dependent degradation of key sarcomeric proteins, such as alpha-actinin (ACTN2) and filamin-C (FLNC), essential for maintenance of normal contractile function.|
|Cellular Location||Cytoplasm, myofibril, sarcomere, Z line|
|Tissue Location||Predominantly expressed in liver, also enriched in cardiac muscle.|
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Provided below are standard protocols that you may find useful for product applications.
This gene encodes a member of the F-box protein family which is characterized by an approximately 40 amino acid motif, the F-box. The F-box proteins constitute one of the four subunits of the ubiquitin protein ligase complex called SCFs (SKP1-cullin-F-box), which function in phosphorylation-dependent ubiquitination. The F-box proteins are divided into 3 classes: Fbws containing WD-40 domains, Fbls containing leucine-rich repeats, and Fbxs containing either different protein-protein interaction modules or no recognizable motifs. The protein encoded by this gene belongs to the Fbxs class. Two transcript variants encoding different isoforms exist for this gene.
Borziak, K., et al. Bioinformatics 23(19):2518-2521(2007)
Lamesch, P., et al. Genomics 89(3):307-315(2007)
Winston, J.T., et al. Curr. Biol. 9(20):1180-1182(1999)
Cenciarelli, C., et al. Curr. Biol. 9(20):1177-1179(1999)
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