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>   home   >   Products   >   Primary Antibodies   >   Cell Biology   >   FBXO22 Antibody (C-term)   

FBXO22 Antibody (C-term)

Peptide Affinity Purified Rabbit Polyclonal Antibody (Pab)

  • WB - FBXO22 Antibody (C-term) AP18732b
    FBXO22 Antibody (C-term)(Cat. #AP18732b) western blot analysis in mouse heart tissue lysates (35ug/lane).This demonstrates the FBXO22 antibody detected the FBXO22 protein (arrow).
Product Information
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
Primary Accession Q8NEZ5
Other Accession Q78JE5, NP_036302.1
Reactivity Mouse
Host Rabbit
Clonality Polyclonal
Isotype Rabbit Ig
Calculated MW 44508 Da
Antigen Region 320-347 aa
Additional Information
Gene ID 26263
Other Names F-box only protein 22, F-box protein FBX22p44, FBXO22, FBX22
Target/Specificity This FBXO22 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 320-347 amino acids from the C-terminal region of human FBXO22.
Dilution WB~~1:1000
Format Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.
StorageMaintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
PrecautionsFBXO22 Antibody (C-term) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name FBXO22
Synonyms FBX22
Function Substrate-recognition component of the SCF (SKP1-CUL1-F- box protein)-type E3 ubiquitin ligase complex. Promotes the proteasome-dependent degradation of key sarcomeric proteins, such as alpha-actinin (ACTN2) and filamin-C (FLNC), essential for maintenance of normal contractile function.
Cellular Location Cytoplasm, myofibril, sarcomere, Z line
Tissue Location Predominantly expressed in liver, also enriched in cardiac muscle.
Research Areas
Citations (0)

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This gene encodes a member of the F-box protein family which is characterized by an approximately 40 amino acid motif, the F-box. The F-box proteins constitute one of the four subunits of the ubiquitin protein ligase complex called SCFs (SKP1-cullin-F-box), which function in phosphorylation-dependent ubiquitination. The F-box proteins are divided into 3 classes: Fbws containing WD-40 domains, Fbls containing leucine-rich repeats, and Fbxs containing either different protein-protein interaction modules or no recognizable motifs. The protein encoded by this gene belongs to the Fbxs class. Two transcript variants encoding different isoforms exist for this gene.


Borziak, K., et al. Bioinformatics 23(19):2518-2521(2007)
Lamesch, P., et al. Genomics 89(3):307-315(2007)
Winston, J.T., et al. Curr. Biol. 9(20):1180-1182(1999)
Cenciarelli, C., et al. Curr. Biol. 9(20):1177-1179(1999)

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$ 295.00
$ 99.00
Cat# AP18732b
(40 western blots)
Availability: In Stock
Bulk Size
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