|Application ||WB, E|
|Antigen Region||219-247 aa|
|Other Names||28S ribosomal protein S31, mitochondrial, MRP-S31, S31mt, Imogen 38, MRPS31, IMOGN38|
|Target/Specificity||This MRPS31 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 219-247 amino acids from the Central region of human MRPS31.|
|Format||Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||MRPS31 Antibody (Center) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Cellular Location||Mitochondrion. EMBL; Z68747; CAA92951.1; -; mRNA EMBL; AK315248; BAG37670.1; -; mRNA EMBL; AL355132; CAH70977.1; -; Genomic_DNA EMBL; AL161614; CAH70977.1; JOINED; Genomic_DNA EMBL; AL161614; CAH72771.1; -; Genomic_DNA EMBL; AL355132; CAH72771.1; JOINED; Genomic_DNA EMBL; CH471075; EAX08629.1; -; Genomic_DNA EMBL; BC022045; AAH22045.1; -; mRNA CCDS; CCDS9372.1; - RefSeq; NP_005821.2; NM_005830.3 UniGene; Hs.596607; - PDB; 3J9M; EM; 3.50 A; AY=1-395 PDBsum; 3J9M; - ProteinModelPortal; Q92665; - SMR; Q92665; - BioGrid; 115534; 71 IntAct; Q92665; 16 MINT; MINT-1420773; - STRING; 9606.ENSP00000315397; - iPTMnet; Q92665; - PhosphoSitePlus; Q92665; - BioMuta; MRPS31; - DMDM; 93186129; - EPD; Q92665; - MaxQB; Q92665; - PaxDb; Q92665; - PeptideAtlas; Q92665; - PRIDE; Q92665; - DNASU; 10240; - Ensembl; ENST00000323563; ENSP00000315397; ENSG00000102738 GeneID; 10240; - KEGG; hsa:10240; - UCSC; uc001uxm.5; human CTD; 10240; - DisGeNET; 10240; - GeneCards; MRPS31; - HGNC; HGNC:16632; MRPS31 HPA; HPA039083; - HPA; HPA046344; - MIM; 611992; gene neXtProt; NX_Q92665; - OpenTargets; ENSG00000102738; - PharmGKB; PA31019; - eggNOG; ENOG410IHXJ; Eukaryota eggNOG; ENOG4111GGB; LUCA GeneTree; ENSGT00390000010017; - HOGENOM; HOG000232111; - HOVERGEN; HBG036128; - InParanoid; Q92665; - KO; K17410; - OMA; KESNIQF; - OrthoDB; EOG091G0LP5; - PhylomeDB; Q92665; - TreeFam; TF324305; - BioCyc; ZFISH:ENSG00000102738-MONOMER; - Reactome; R-HSA-5368286; Mitochondrial translation initiation Reactome; R-HSA-5389840; Mitochondrial translation elongation Reactome; R-HSA-5419276; Mitochondrial translation termination GenomeRNAi; 10240; - PRO; PR:Q92665; - Proteomes; UP000005640; Chromosome 13 Bgee; ENSG00000102738; - CleanEx; HS_MRPS31; - Genevisible; Q92665; HS GO; GO:0005743; C:mitochondrial inner membrane; TAS:Reactome GO; GO:0005763; C:mitochondrial small ribosomal subunit; IEA:InterPro GO; GO:0005739; C:mitochondrion; IDA:HPA GO; GO:0005730; C:nucleolus; IDA:HPA GO; GO:0044822; F:poly(A) RNA binding; IDA:UniProtKB GO; GO:0019904; F:protein domain specific binding; IPI:UniProtKB GO; GO:0003735; F:structural constituent of ribosome; IEA:InterPro GO; GO:0070125; P:mitochondrial translational elongation; TAS:Reactome GO; GO:0070126; P:mitochondrial translational termination; TAS:Reactome InterPro; IPR026299; MRP-S31 PANTHER; PTHR13231; PTHR13231; 1 Pfam; PF15433; MRP-S31; 1 1: Evidence at protein level; 3D-structure; Complete proteome; Mitochondrion; Polymorphism; Reference proteome; Ribonucleoprotein; Ribosomal protein; Transit peptide TRANSIT 1 65 Mitochondrion. CHAIN 66 395 28S ribosomal protein S31, mitochondrial /FTId=PRO_0000030594 VARIANT 241 241 T -> M (in dbSNP:rs1854421) /FTId=VAR_052049 VARIANT 279 279 D -> N (in dbSNP:rs13508) /FTId=VAR_061812 CONFLICT 80 80 T -> I (in Ref. 5; AAH22045) CONFLICT 132 132 T -> A (in Ref. 5; AAH22045) SEQUENCE 395 AA; 45318 MW; 01ED04983ED56818 CRC64; MFPRVSTFLP LRPLSRHPLS SGSPETSAAA IMLLTVRHGT VRYRSSALLA RTKNNIQRYF GTNSVICSKK DKQSVRTEET SKETSESQDS EKENTKKDLL GIIKGMKVEL STVNVRTTKP PKRRPLKSLE ATLGRLRRAT EYAPKKRIEP LSPELVAAAS AVADSLPFDK QTTKSELLSQ LQQHEEESRA QRDAKRPKIS FSNIISDMKV ARSATARVRS RPELRIQFDE GYDNYPGQEK TDDLKKRKNI FTGKRLNIFD MMAVTKEAPE TDTSPSLWDV EFAKQLATVN EQPLQNGFEE LIQWTKEGKL WEFPINNEAG FDDDGSEFHE HIFLEKHLES FPKQGPIRHF MELVTCGLSK NPYLSVKQKV EHIEWFRNYF NEKKDILKES NIQFN|
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Provided below are standard protocols that you may find useful for product applications.
Mammalian mitochondrial ribosomal proteins are encoded by nuclear genes and help in protein synthesis within the mitochondrion. Mitochondrial ribosomes (mitoribosomes) consist of a small 28S subunit and a large 39S subunit. They have an estimated 75% protein to rRNA composition compared to prokaryotic ribosomes, where this ratio is reversed. Another difference between mammalian mitoribosomes and prokaryotic ribosomes is that the latter contain a 5S rRNA. Among different species, the proteins comprising the mitoribosome differ greatly in sequence, and sometimes in biochemical properties, which prevents easy recognition by sequence homology. The 28S subunit of the mammalian mitoribosome may play a crucial and characteristic role in translation initiation. This gene encodes a 28S subunit protein that has also been associated with type 1 diabetes; however, its relationship to the etiology of this disease remains to be clarified. Pseudogenes corresponding to this gene have been found on chromosomes 3 and 13. [provided by RefSeq].
Dunham, A., et al. Nature 428(6982):522-528(2004)
Zhang, Z., et al. Genomics 81(5):468-480(2003)
Tchernev, V.T., et al. Mol. Med. 8(1):56-64(2002)
Cavdar Koc, E., et al. J. Biol. Chem. 276(22):19363-19374(2001)
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