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NLRP4 Antibody (N-term)

Peptide Affinity Purified Rabbit Polyclonal Antibody (Pab)

  • WB - NLRP4 Antibody (N-term) AP18739a
    NLRP4 Antibody (N-term)(Cat. #AP18739a) western blot analysis in Uterus tissue lysates (35ug/lane).This demonstrates the NLRP4 antibody detected the NLRP4 protein (arrow).
Product Information
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
Primary Accession Q96MN2
Other Accession NP_604393.2
Reactivity Human
Host Rabbit
Clonality Polyclonal
Isotype Rabbit Ig
Calculated MW 113415 Da
Antigen Region 121-149 aa
Additional Information
Gene ID 147945
Other Names NACHT, LRR and PYD domains-containing protein 4, Cancer/testis antigen 58, CT58, PAAD and NACHT-containing protein 2, PAN2, PYRIN and NACHT-containing protein 2, PYRIN-containing APAF1-like protein 4, PYPAF4, Ribonuclease inhibitor 2, NLRP4, NALP4, PAN2, PYPAF4, RNH2
Target/Specificity This NLRP4 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 121-149 amino acids from the N-terminal region of human NLRP4.
Dilution WB~~1:1000
Format Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.
StorageMaintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
PrecautionsNLRP4 Antibody (N-term) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name NLRP4
Synonyms NALP4, PAN2, PYPAF4, RNH2
Function May be involved in inflammation and recognition of cytosolic pathogen-associated molecular patterns (PAMPs) not intercepted by membrane-bound receptors. Acts as a negative regulator of the type I interferon signaling pathway by serving as an adapter to promote DTX4-mediated ubiquitination of activated TBK1, and its subsequent degradation. Suppresses NF-kappaB induction by the cytokines TNFA and IL1B, suggesting that it operates at a point of convergence in these two cytokine signaling pathways.
Research Areas
Citations (0)

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NALPs are cytoplasmic proteins that form a subfamily within the larger CATERPILLER protein family. Most short NALPs, such as NALP4, have an N-terminal pyrin (MEFV; MIM 608107) domain (PYD), followed by a NACHT domain, a NACHT-associated domain (NAD), and a C-terminal leucine-rich repeat (LRR) region. The long NALP, NALP1 (MIM 606636), also has a C-terminal extension containing a function to find domain (FIIND) and a caspase recruitment domain (CARD). NALPs are implicated in the activation of proinflammatory caspases (e.g., CASP1; MIM 147678) via their involvement in multiprotein complexes called inflammasomes (Tschopp et al., 2003 [PubMed 12563287]).


Cummings, J.R., et al. Tissue Antigens 76(1):48-56(2010) Enjuanes, A., et al. Cancer Res. 68(24):10178-10186(2008) Damiano, J.S., et al. Biochem. J. 381 (PT 1), 213-219 (2004) : Tschopp, J., et al. Nat. Rev. Mol. Cell Biol. 4(2):95-104(2003) Grenier, J.M., et al. FEBS Lett. 530 (1-3), 73-78 (2002) :

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$ 295.00
$ 99.00
Cat# AP18739a
(40 western blots)
Availability: In Stock
Bulk Size
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