|Application ||WB, E|
|Other Accession||B0BN85, Q9CX34, Q2KIK0, NP_001124384.1|
|Predicted||Bovine, Mouse, Rat|
|Calculated MW||41024 Da|
|Antigen Region||330-356 aa|
|Other Names||Suppressor of G2 allele of SKP1 homolog, Protein 40-6-3, Sgt1, SUGT1|
|Target/Specificity||This SUGT1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 330-356 amino acids from the C-terminal region of human SUGT1.|
|Format||Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||SUGT1 Antibody (C-term) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||May play a role in ubiquitination and subsequent proteasomal degradation of target proteins.|
|Cellular Location||Cytoplasm. Nucleus. Note=Translocates to the nucleus upon heat shock, requiring S100A6|
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Provided below are standard protocols that you may find useful for product applications.
This gene is homologous to the yeast gene SGT1, which encodes a protein involved in kinetochore function and required for the G1/S and G2/M transitions. Complementation studies suggest that the human protein has similar functions. Two transcript variants encoding different isoforms have been found for this gene.
Davies, A.E., et al. J. Cell Biol. 189(2):261-274(2010)
Iwatsuki, M., et al. Int. J. Oncol. 36(3):569-575(2010)
Bansal, P.K., et al. J. Biol. Chem. 284(28):18692-18698(2009)
Zabka, M., et al. Biochem. Biophys. Res. Commun. 370(1):179-183(2008)
Spiechowicz, M., et al. Biochem. Biophys. Res. Commun. 357(4):1148-1153(2007)
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