|Application ||WB, E|
|Calculated MW||46598 Da|
|Antigen Region||46-72 aa|
|Other Names||DNA dC->dU-editing enzyme APOBEC-3D, A3D, 354-, APOBEC3D|
|Target/Specificity||This APOBEC3D antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 46-72 amino acids from the N-terminal region of human APOBEC3D.|
|Format||Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||APOBEC3D Antibody (N-term) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||DNA deaminase (cytidine deaminase) which acts as an inhibitor of retrovirus replication and retrotransposon mobility via deaminase-dependent and -independent mechanisms. Exhibits antiviral activity against vif-deficient HIV-1. After the penetration of retroviral nucleocapsids into target cells of infection and the initiation of reverse transcription, it can induce the conversion of cytosine to uracil in the minus-sense single-strand viral DNA, leading to G-to-A hypermutations in the subsequent plus-strand viral DNA. The resultant detrimental levels of mutations in the proviral genome, along with a deamination- independent mechanism that works prior to the proviral integration, together exert efficient antiretroviral effects in infected target cells. Selectively targets single-stranded DNA and does not deaminate double-stranded DNA or single-or double- stranded RNA. May inhibit the mobility of LTR and non-LTR retrotransposons.|
|Cellular Location||Cytoplasm. Cytoplasm, P-body.|
|Tissue Location||Expressed in lymphoid organs. Also detected in non-lymphoid tissues including lung|
Thousands of laboratories across the world have published research that depended on the performance of antibodies from Abgent to advance their research. Check out links to articles that cite our products in major peer-reviewed journals, organized by research category.
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Provided below are standard protocols that you may find useful for product applications.
Unknown. Unable to reduce HIV-1 infectivity in vitro.
Zhang, W., et al. PLoS ONE 3 (12), E3963 (2008) :
Dang, Y., et al. J. Virol. 80(21):10522-10533(2006)
Stenglein, M.D., et al. J. Biol. Chem. 281(25):16837-16841(2006)
Conticello, S.G., et al. Mol. Biol. Evol. 22(2):367-377(2005)
Harris, R.S., et al. Nat. Rev. Immunol. 4(11):868-877(2004)
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