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APOBEC3D Antibody (N-term)

Affinity Purified Rabbit Polyclonal Antibody (Pab)

     
  • WB - APOBEC3D Antibody (N-term) AP18763a
    APOBEC3D Antibody (N-term)(Cat. #AP18763a) western blot analysis in human placenta tissue lysates (35ug/lane).This demonstrates the APOBEC3D antibody detected the APOBEC3D protein (arrow).
    detail
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Product Information
Application
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • E=ELISA
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
WB, E
Primary Accession Q96AK3
Other Accession NP_689639.2
Reactivity Human
Host Rabbit
Clonality Polyclonal
Isotype Rabbit IgG
Calculated MW 46598 Da
Antigen Region 46-72 aa
Additional Information
Other Names DNA dC->dU-editing enzyme APOBEC-3D, A3D, 354-, APOBEC3D
Target/Specificity This APOBEC3D antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 46-72 amino acids from the N-terminal region of human APOBEC3D.
Dilution WB~~1:1000
Format Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.
StorageMaintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
PrecautionsAPOBEC3D Antibody (N-term) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name APOBEC3D (HGNC:17354)
Function DNA deaminase (cytidine deaminase) which acts as an inhibitor of retrovirus replication and retrotransposon mobility via deaminase- dependent and -independent mechanisms (PubMed:16920826, PubMed:20062055, PubMed:21835787). Exhibits antiviral activity against HIV-1. After the penetration of retroviral nucleocapsids into target cells of infection and the initiation of reverse transcription, it can induce the conversion of cytosine to uracil in the minus-sense single- strand viral DNA, leading to G-to-A hypermutations in the subsequent plus-strand viral DNA (PubMed:16920826). The resultant detrimental levels of mutations in the proviral genome, along with a deamination- independent mechanism that works prior to the proviral integration, together exert efficient antiretroviral effects in infected target cells. Selectively targets single-stranded DNA and does not deaminate double-stranded DNA or single- or double-stranded RNA. Inhibits also the mobility of LTR and non-LTR retrotransposons (PubMed:27428332).
Cellular Location Cytoplasm. Cytoplasm, P-body
Tissue Location Expressed in lymphoid organs. Also detected in non- lymphoid tissues including lung.
Research Areas
Citations (0)
citation

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Background

Unknown. Unable to reduce HIV-1 infectivity in vitro.

References

Zhang, W., et al. PLoS ONE 3 (12), E3963 (2008) :
Dang, Y., et al. J. Virol. 80(21):10522-10533(2006)
Stenglein, M.D., et al. J. Biol. Chem. 281(25):16837-16841(2006)
Conticello, S.G., et al. Mol. Biol. Evol. 22(2):367-377(2005)
Harris, R.S., et al. Nat. Rev. Immunol. 4(11):868-877(2004)

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$ 182.50
$ 70.00
Cat# AP18763a
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