|Application ||WB, E|
|Other Accession||P0C7T6, NP_001131147.1|
|Calculated MW||73306 Da|
|Antigen Region||385-411 aa|
|Other Names||Ataxin-1-like, Brother of ataxin-1, Brother of ATXN1, ATXN1L, BOAT, BOAT1|
|Target/Specificity||This ATXN1L antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 385-411 amino acids from the Central region of human ATXN1L.|
|Format||Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||ATXN1L Antibody (Center) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Chromatin-binding factor that repress Notch signaling in the absence of Notch intracellular domain by acting as a CBF1 corepressor. Binds to the HEY promoter and might assist, along with NCOR2, RBPJ-mediated repression. Can suppress ATXN1 cytotoxicity in spinocerebellar ataxia type 1 (SCA1) (By similarity).|
|Cellular Location||Nucleus. Cell projection, dendrite. Note=Forms nuclear foci. Colocalizes with NCOR2 and HDAC3. Distributed beyond the nucleus into the cell body and dendrites in Purkinje cells and in inferior olive cells|
|Tissue Location||Expressed in cerebellum and cerebral cortex.|
Thousands of laboratories across the world have published research that depended on the performance of antibodies from Abgent to advance their research. Check out links to articles that cite our products in major peer-reviewed journals, organized by research category.
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Provided below are standard protocols that you may find useful for product applications.
ATXN1L can suppress the cytotoxicity of ATXN1 in spinocerebellar ataxia type 1 (SCA1) (By similarity).
Bowman, A.B., et al. Nat. Genet. 39(3):373-379(2007)
Mizutani, A., et al. EMBO J. 24(18):3339-3351(2005)
Venter, J.C., et al. Science 291(5507):1304-1351(2001)
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