ATXN1L Antibody (Center)
Affinity Purified Rabbit Polyclonal Antibody (Pab)
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application
| WB, E |
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Primary Accession | P0C7T5 |
Other Accession | P0C7T6, NP_001131147.1 |
Reactivity | Human |
Predicted | Mouse |
Host | Rabbit |
Clonality | Polyclonal |
Isotype | Rabbit IgG |
Calculated MW | 73306 Da |
Antigen Region | 385-411 aa |
Gene ID | 342371 |
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Other Names | Ataxin-1-like, Brother of ataxin-1, Brother of ATXN1, ATXN1L, BOAT, BOAT1 |
Target/Specificity | This ATXN1L antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 385-411 amino acids from the Central region of human ATXN1L. |
Dilution | WB~~1:1000 |
Format | Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification. |
Storage | Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. |
Precautions | ATXN1L Antibody (Center) is for research use only and not for use in diagnostic or therapeutic procedures. |
Name | ATXN1L |
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Synonyms | BOAT, BOAT1 |
Function | Chromatin-binding factor that repress Notch signaling in the absence of Notch intracellular domain by acting as a CBF1 corepressor. Binds to the HEY promoter and might assist, along with NCOR2, RBPJ- mediated repression (PubMed:21475249). Can suppress ATXN1 cytotoxicity in spinocerebellar ataxia type 1 (SCA1). In concert with CIC and ATXN1, involved in brain development (By similarity). |
Cellular Location | Nucleus. Cell projection, dendrite. Note=Forms nuclear foci. Colocalizes with NCOR2 and HDAC3. Distributed beyond the nucleus into the cell body and dendrites in Purkinje cells and in inferior olive cells |
Tissue Location | Expressed in cerebellum and cerebral cortex. |
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Provided below are standard protocols that you may find useful for product applications.
Background
ATXN1L can suppress the cytotoxicity of ATXN1 in spinocerebellar ataxia type 1 (SCA1) (By similarity).
References
Bowman, A.B., et al. Nat. Genet. 39(3):373-379(2007)
Mizutani, A., et al. EMBO J. 24(18):3339-3351(2005)
Venter, J.C., et al. Science 291(5507):1304-1351(2001)
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