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DHX36 Antibody (Center)

Peptide Affinity Purified Rabbit Polyclonal Antibody (Pab)

  • WB - DHX36 Antibody (Center) AP18778C
    DHX36 Antibody (Center)(Cat. #AP18778c) western blot analysis in HepG2 cell line lysates (35ug/lane).This demonstrates the DHX36 antibody detected the DHX36 protein (arrow).
Product Information
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
Primary Accession Q9H2U1
Other Accession NP_001107869.1
Reactivity Human
Host Rabbit
Clonality Polyclonal
Isotype Rabbit Ig
Calculated MW 114760 Da
Antigen Region 394-420 aa
Additional Information
Gene ID 170506
Other Names ATP-dependent RNA helicase DHX36, DEAH box protein 36, G4-resolvase 1, G4R1, MLE-like protein 1, RNA helicase associated with AU-rich element ARE, DHX36, DDX36, KIAA1488, MLEL1, RHAU
Target/Specificity This DHX36 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 394-420 amino acids from the Central region of human DHX36.
Dilution WB~~1:1000
Format Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.
StorageMaintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
PrecautionsDHX36 Antibody (Center) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name DHX36
Synonyms DDX36, KIAA1488, MLEL1, RHAU
Function Proposed to have a global role in regulating mRNA expression including transcriptional regulation and mRNA stability. Binds with high affinity to and resolves tetramolecular RNA and DNA quadruplex structures. Unwinds intramolecular quadruplexes derived from the ZIC1 and the MYC promoters. Binds to quadruplex structures in the promoters of YY1 and ALPL genes and regulates their expression. Binds to telomerase RNA template component (TERC) 5'-end (nucleotides 1-43) and unwinds an internal quadruplex formation in TERC 5'-end to promote P1 helix formation; the P1 helix acts as a template boundary ensuring accurate reverse transcription and is disrupted by quadruplex formation. May be involved in regulation of telomere length. Plays a role in degradation and deadenylation of mRNAs containing in their 3'-UTR the consensus ARE sequence element. May function in sex development and spermatogenesis. May play a role in ossification.
Cellular Location Nucleus. Cytoplasm. Chromosome, telomere. Note=Isoform 1 preferentially localized to the nucleus and isoform 2 localized to the cytoplasm. However, partitioning of cellular localization between the nucleus and cytoplasm is not exclusive, as isoform 1 was also detected in the cytoplasm. Both isoforms were excluded from nucleoli. Localizes to cytoplasmic stress granules
Tissue Location Highly expressed in testis.
Citations (0)

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This gene is a member of the DEAH-box family of RNA-dependent NTPases which are named after the conserved amino acid sequence Asp-Glu-Ala-His in motif II. The protein encoded by this gene has been shown to enhance the deadenylation and decay of mRNAs with 3'-UTR AU-rich elements (ARE-mRNA). The protein has also been shown to resolve into single strands the highly stable tetramolecular DNA configuration (G4) that can form spontaneously in guanine-rich regions of DNA. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq].


Lattmann, S., et al. Nucleic Acids Res. 38(18):6219-6233(2010)
Kim, T., et al. Proc. Natl. Acad. Sci. U.S.A. 107(34):15181-15186(2010)
Chalupnikova, K., et al. J. Biol. Chem. 283(50):35186-35198(2008)
Creacy, S.D., et al. J. Biol. Chem. 283(50):34626-34634(2008)
Iwamoto, F., et al. Exp. Cell Res. 314(6):1378-1391(2008)

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$ 295.00
$ 99.00
Cat# AP18778C
(40 western blots)
Availability: In Stock
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