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MCF2L Antibody (C-term)

Peptide Affinity Purified Rabbit Polyclonal Antibody (Pab)

     
  • WB - MCF2L Antibody (C-term) AP18793B
    MCF2L Antibody (C-term)(Cat. #AP18793b) western blot analysis in NCI-H460 cell line lysates (35ug/lane).This demonstrates the MCF2L antibody detected the MCF2L protein (arrow).
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Product Information
Application
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • E=ELISA
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
WB, E
Primary Accession O15068
Other Accession NP_001106203.1
Reactivity Human
Host Rabbit
Clonality Polyclonal
Isotype Rabbit Ig
Calculated MW 128109 Da
Antigen Region 1049-1075 aa
Additional Information
Gene ID 23263
Other Names Guanine nucleotide exchange factor DBS, DBL's big sister, MCF2-transforming sequence-like protein, MCF2L, KIAA0362
Target/Specificity This MCF2L antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 1049-1075 amino acids from the C-terminal region of human MCF2L.
Dilution WB~~1:1000
Format Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.
StorageMaintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
PrecautionsMCF2L Antibody (C-term) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name MCF2L
Synonyms KIAA0362, OST {ECO:0000303|PubMed:151576
Function Guanine nucleotide exchange factor that catalyzes guanine nucleotide exchange on RHOA and CDC42, and thereby contributes to the regulation of RHOA and CDC42 signaling pathways (By similarity). Seems to lack activity with RAC1. Becomes activated and highly tumorigenic by truncation of the N-terminus (By similarity). Isoform 5 activates CDC42 (PubMed:15157669).
Cellular Location Isoform 5: Cytoplasm. Cell membrane; Peripheral membrane protein; Cytoplasmic side Cytoplasm {ECO:0000250|UniProtKB:Q64096}. Cell membrane {ECO:0000250|UniProtKB:Q64096}; Peripheral membrane protein {ECO:0000250|UniProtKB:Q64096}; Cytoplasmic side {ECO:0000250|UniProtKB:Q64096}
Research Areas
Citations (0)

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Background

Guanine nucleotide exchange factor that potentially links pathways that signal through RAC1, RHOA and CDC42. Catalyzes guanine nucleotide exchange on RHOA and CDC42 and interacts specifically with the GTP-bound form of RAC1, suggesting that it functions as an effector of RAC1. May also participate in axonal transport in the brain. Becomes activated and highly tumorigenic by truncation of the N-terminus (By similarity). Isoform 5 activates CDC42.

References

Rose, J.E., et al. Mol. Med. 16 (7-8), 247-253 (2010) :
Takefuji, M., et al. J. Hum. Genet. 55(1):42-49(2010)
Ieguchi, K., et al. J. Biol. Chem. 282(32):23296-23305(2007)
Yang, Q., et al. BMC Med. Genet. 8 SUPPL 1, S12 (2007) :
Kostenko, E.V., et al. J. Biol. Chem. 280(4):2807-2817(2005)

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Cat# AP18793B
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