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SFN Antibody (Center)

Peptide Affinity Purified Rabbit Polyclonal Antibody (Pab)

     
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  • WB - SFN Antibody (Center) AP18803c
    SFN Antibody (Center) (Cat. #AP18803c) western blot analysis in A431 cell line and mouse bladder tissue lysates (35ug/lane).This demonstrates the SFN antibody detected the SFN protein (arrow).
  • SPECIFICATION
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Product Information
Application
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • E=ELISA
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
WB, E
Primary Accession P31947
Other Accession O70456, Q0VC36, NP_006133.1, O77642
Reactivity Human, Mouse
Predicted Bovine
Host Rabbit
Clonality Polyclonal
Isotype Rabbit Ig
Calculated MW 27774 Da
Antigen Region 120-149 aa
Additional Information
Gene ID 2810
Other Names 14-3-3 protein sigma, Epithelial cell marker protein 1, Stratifin, SFN, HME1
Target/Specificity This SFN antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 120-149 amino acids from the Central region of human SFN.
Dilution WB~~1:1000
Format Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.
StorageMaintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
PrecautionsSFN Antibody (Center) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name SFN
Synonyms HME1
Function Adapter protein implicated in the regulation of a large spectrum of both general and specialized signaling pathways. Binds to a large number of partners, usually by recognition of a phosphoserine or phosphothreonine motif. Binding generally results in the modulation of the activity of the binding partner. When bound to KRT17, regulates protein synthesis and epithelial cell growth by stimulating Akt/mTOR pathway. May also regulate MDM2 autoubiquitination and degradation and thereby activate p53/TP53.
Cellular Location Cytoplasm. Nucleus. Secreted. Note=May be secreted by a non-classical secretory pathway
Tissue Location Present mainly in tissues enriched in stratified squamous keratinizing epithelium
Research Areas
Citations (0)

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Background

Adapter protein implicated in the regulation of a large spectrum of both general and specialized signaling pathway. Binds to a large number of partners, usually by recognition of a phosphoserine or phosphothreonine motif. Binding generally results in the modulation of the activity of the binding partner. When bound to KRT17, regulates protein synthesis and epithelial cell growth by stimulating Akt/mTOR pathway (By similarity). p53-regulated inhibitor of G2/M progression.

References

Ren, H.Z., et al. Dig. Dis. Sci. 55(9):2552-2560(2010)
Liu, Y., et al. Brain Res. 1336, 98-102 (2010) :
Pei, H.P., et al. Zhonghua Wei Chang Wai Ke Za Zhi 13(3):213-215(2010)
Syrjanen, S., et al. Am. J. Clin. Pathol. 133(2):232-240(2010)
Zurita, M., et al. BMC Cancer 10, 217 (2010) :

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$ 295.00
$ 99.00
Cat# AP18803c
Size:
Quantity:
(40 western blots)
Availability: In Stock
Bulk Size
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