|Application ||WB, E|
|Calculated MW||123342 Da|
|Antigen Region||455-484 aa|
|Other Names||Neurabin-1, Neurabin-I, Neural tissue-specific F-actin-binding protein I, Protein phosphatase 1 regulatory subunit 9A, PPP1R9A, KIAA1222|
|Target/Specificity||This PPP1R9A antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 455-484 amino acids from the Central region of human PPP1R9A.|
|Format||Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||PPP1R9A Antibody (Center) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Binds to actin filaments (F-actin) and shows cross- linking activity. Binds along the sides of the F-actin. May be involved in neurite formation. Inhibits protein phosphatase 1- alpha activity (By similarity).|
|Cellular Location||Cytoplasm, cytoskeleton. Cell junction, synapse, synaptosome|
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Provided below are standard protocols that you may find useful for product applications.
This gene is imprinted, and located in a cluster of imprinted genes on chromosome 7q12. This gene is transcribed in both neuronal and multiple embryonic tissues, and it is maternally expressed mainly in embryonic skeletal muscle tissues and biallelically expressed in other embryonic tissues. The protein encoded by this gene includes a PDZ domain and a sterile alpha motif (SAM). It is a regulatory subunit of protein phosphatase I, and controls actin cytoskeleton reorganization. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.
Bailey, S.D., et al. Diabetes Care 33(10):2250-2253(2010)
Suarez-Gestal, M., et al. Arthritis Res. Ther. 12 (2), R72 (2010) :
Talmud, P.J., et al. Am. J. Hum. Genet. 85(5):628-642(2009)
Nakabayashi, K., et al. J. Med. Genet. 41(8):601-608(2004)
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