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GINS2 Antibody (Center)
Affinity Purified Rabbit Polyclonal Antibody (Pab)
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application 
| WB, E |
|---|---|
| Primary Accession | Q9Y248 |
| Other Accession | Q7ZT46, NP_057179.1 |
| Reactivity | Human |
| Predicted | Xenopus |
| Host | Rabbit |
| Clonality | Polyclonal |
| Isotype | Rabbit IgG |
| Calculated MW | 21428 Da |
| Antigen Region | 90-119 aa |
| Gene ID | 51659 |
|---|---|
| Other Names | DNA replication complex GINS protein PSF2, GINS complex subunit 2, GINS2, PSF2 |
| Target/Specificity | This GINS2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 90-119 amino acids from the Central region of human GINS2. |
| Dilution | WB~~1:1000 |
| Format | Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification. |
| Storage | Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. |
| Precautions | GINS2 Antibody (Center) is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | GINS2 (HGNC:24575) |
|---|---|
| Synonyms | PSF2 |
| Function | Required for correct functioning of the GINS complex, a complex that plays an essential role in the initiation of DNA replication, and progression of DNA replication forks (PubMed:17417653). GINS complex is a core component of CDC45-MCM-GINS (CMG) helicase, the molecular machine that unwinds template DNA during replication, and around which the replisome is built (PubMed:32453425, PubMed:34694004, PubMed:34700328, PubMed:35585232). |
| Cellular Location | Nucleus. Chromosome. Note=Associates with chromatin |
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Provided below are standard protocols that you may find useful for product applications.
Background
The yeast heterotetrameric GINS complex is made up of Sld5 (GINS4; MIM 610611), Psf1 (GINS1; MIM 610608), Psf2, and Psf3 (GINS3; MIM 610610). The formation of this complex is essential for the initiation of DNA replication in yeast and Xenopus egg extracts (Ueno et al., 2005 [PubMed 16287864]). See GINS1 for additional information about the GINS complex.
References
Matsuoka, S., et al. Science 316(5828):1160-1166(2007)
Matsuoka, S., et al. Science 316(5828):1160-1166(2007)
Lamesch, P., et al. Genomics 89(3):307-315(2007)
Takayama, Y., et al. Genes Dev. 17(9):1153-1165(2003)
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