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GPRC6A Antibody (Center)

Peptide Affinity Purified Rabbit Polyclonal Antibody (Pab)

  • WB - GPRC6A Antibody (Center) AP18812c
    GPRC6A Antibody (Center)(Cat. #AP18812c) western blot analysis in human placenta tissue lysates (35ug/lane).This demonstrates the GPRC6A antibody detected the GPRC6A protein (arrow).
Product Information
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
Primary Accession Q5T6X5
Other Accession NP_683766.2
Reactivity Human
Host Rabbit
Clonality Polyclonal
Isotype Rabbit Ig
Calculated MW 104753 Da
Antigen Region 489-517 aa
Additional Information
Gene ID 222545
Other Names G-protein coupled receptor family C group 6 member A, hGPRC6A, G-protein coupled receptor GPCR33, hGPCR33, GPRC6A
Target/Specificity This GPRC6A antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 489-517 amino acids from the Central region of human GPRC6A.
Dilution WB~~1:1000
Format Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.
StorageMaintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
PrecautionsGPRC6A Antibody (Center) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Function Receptor activated by amino acids with a preference for basic amino acids such as L-Lys, L-Arg and L-ornithine but also by small and polar amino acids. The L-alpha amino acids respond is augmented by divalent cations Ca(2+) and Mg(2+). Activated by extracellular calcium and osteocalin. Seems to act through a G(q)/G(11) and G(i)-coupled pathway. Mediates the non-genomic effects of androgens in multiple tissue. May coordinates nutritional and hormonal anabolic signals through the sensing of extracellular amino acids, osteocalcin, divalents ions and its responsiveness to anabolic steroids.
Cellular Location Cell membrane; Multi-pass membrane protein
Tissue Location Isoform 1 is expressed at high level in brain, skeletal muscle, testis, bone, calvaria, osteoblasts and leukocytes. Expressed at intermediate level in liver, heart, kidney and spleen. Expressed at low level in lung, pancreas, placenta and ovary. Not detected in thymus, prostate, small intestine, tongue and colon. Isoform 1 and isoform 2 are expressed in kidney at the same level. Isoform 2 is expressed at lower level than isoform 1 in the other tissues
Research Areas
Citations (0)

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Members of family C of the G protein-coupled receptor (GPCR) superfamily, such as GPRC6A, are characterized by an evolutionarily conserved amino acid-sensing motif linked to an intramembranous 7-transmembrane loop region. Several members of GPCR family C, including GPRC6A, also have a long N-terminal domain (summary by Pi et al., 2005 [PubMed 16199532]).


Giroux, S., et al. Bone 47(5):975-981(2010)
Takata, R., et al. Nat. Genet. 42(9):751-754(2010)
Pi, M., et al. J. Bone Miner. Res. 25(5):1092-1102(2010)
Dowal, L., et al. J. Biol. Chem. 281(33):23999-24014(2006)
Pi, M., et al. J. Biol. Chem. 280(48):40201-40209(2005)

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$ 295.00
$ 99.00
Cat# AP18812c
(40 western blots)
Availability: In Stock
Bulk Size
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