|Application ||WB, E|
|Other Accession||Q08850, P70452, Q3SWZ3, NP_004595.2|
|Predicted||Bovine, Mouse, Rat|
|Calculated MW||34180 Da|
|Antigen Region||132-160 aa|
|Other Names||Syntaxin-4, Renal carcinoma antigen NY-REN-31, STX4, STX4A|
|Target/Specificity||This STX4 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 132-160 amino acids from the Central region of human STX4.|
|Format||Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||STX4 Antibody (Center) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Plasma membrane t-SNARE that mediates docking of transport vesicles. Necessary for the translocation of SLC2A4 from intracellular vesicles to the plasma membrane. Together with STXB3 and VAMP2, may also play a role in docking/fusion of intracellular GLUT4-containing vesicles with the cell surface in adipocytes (By similarity). May also play a role in docking of synaptic vesicles at presynaptic active zones.|
|Cellular Location||Cell membrane; Single-pass type IV membrane protein|
|Tissue Location||Expressed in neutrophils and neutrophil- differentiated HL-60 cells. Expression in neutrophils increases with differentiation.|
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Provided below are standard protocols that you may find useful for product applications.
Plasma membrane t-SNARE that mediates docking of transport vesicles. Necessary for the translocation of SLC2A4 from intracellular vesicles to the plasma membrane. Together with STXB3 and VAMP2, may also play a role in docking/fusion of intracellular GLUT4-containing vesicles with the cell surface in adipocytes (By similarity). May also play a role in docking of synaptic vesicles at presynaptic active zones.
Evesson, F.J., et al. J. Biol. Chem. 285(37):28529-28539(2010)
Kennedy, M.J., et al. Cell 141(3):524-535(2010)
Brochetta, C., et al. Biochim. Biophys. Acta 1783(10):1781-1791(2008)
Cooper, G.M., et al. Blood 112(4):1022-1027(2008)
Low, S.H., et al. Mol. Biol. Cell 17(2):977-989(2006)
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