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>   home   >   Products   >   Primary Antibodies   >   Signal Transduction   >   SKAP1 Antibody (C-term)   

SKAP1 Antibody (C-term)

Peptide Affinity Purified Rabbit Polyclonal Antibody (Pab)

  • WB - SKAP1 Antibody (C-term) AP18824b
    SKAP1 Antibody (C-term)(Cat. #AP18824b) western blot analysis in MDA-MB453 cell line lysates (35ug/lane).This demonstrates the SKAP1 antibody detected the SKAP1 protein (arrow).
Product Information
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
Primary Accession Q86WV1
Other Accession NP_003717.3
Reactivity Human
Host Rabbit
Clonality Polyclonal
Isotype Rabbit Ig
Calculated MW 41432 Da
Antigen Region 266-295 aa
Additional Information
Gene ID 8631
Other Names Src kinase-associated phosphoprotein 1, Src family-associated phosphoprotein 1, Src kinase-associated phosphoprotein of 55 kDa, SKAP-55, pp55, SKAP1, SCAP1, SKAP55
Target/Specificity This SKAP1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 266-295 amino acids from the C-terminal region of human SKAP1.
Dilution WB~~1:1000
Format Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.
StorageMaintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
PrecautionsSKAP1 Antibody (C-term) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name SKAP1
Synonyms SCAP1, SKAP55
Function Positively regulates T-cell receptor signaling by enhancing the MAP kinase pathway. Required for optimal conjugation between T-cells and antigen-presenting cells by promoting the clustering of integrin ITGAL on the surface of T-cells. May be involved in high affinity immunoglobulin epsilon receptor signaling in mast cells.
Cellular Location Cytoplasm. Nucleus. Cell membrane. Note=Upon T-cell stimulation, translocates to lipid rafts at the cell membrane
Tissue Location Highly expressed in thymocytes and peripheral blood lymphocytes. Also expressed in spleen cells and testis Present in T-cells (at protein level)
Research Areas
Citations (0)

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This gene encodes a T cell adaptor protein, a class of intracellular molecules with modular domains capable of recruiting additional proteins but that exhibit no intrinsic enzymatic activity. The encoded protein contains a unique N-terminal region followed by a PH domain and C-terminal SH3 domain. Along with the adhesion and degranulation-promoting adaptor protein, the encoded protein plays a critical role in inside-out signaling by coupling T-cell antigen receptor stimulation to the activation of integrins.


Goode, E.L., et al. Nat. Genet. 42(10):874-879(2010)
Rose, J.E., et al. Mol. Med. 16 (7-8), 247-253 (2010) :
Raab, M., et al. Immunity 32(4):541-556(2010)
Lehmann, R., et al. Proteomics 9(23):5288-5295(2009)
Fang, L., et al. Cell Cycle 8(17):2819-2827(2009)

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$ 295.00
$ 99.00
Cat# AP18824b
(40 western blots)
Availability: In Stock
Bulk Size
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