|Application ||WB, E|
|Calculated MW||41432 Da|
|Antigen Region||266-295 aa|
|Other Names||Src kinase-associated phosphoprotein 1, Src family-associated phosphoprotein 1, Src kinase-associated phosphoprotein of 55 kDa, SKAP-55, pp55, SKAP1, SCAP1, SKAP55|
|Target/Specificity||This SKAP1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 266-295 amino acids from the C-terminal region of human SKAP1.|
|Format||Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||SKAP1 Antibody (C-term) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Positively regulates T-cell receptor signaling by enhancing the MAP kinase pathway. Required for optimal conjugation between T-cells and antigen-presenting cells by promoting the clustering of integrin ITGAL on the surface of T-cells. May be involved in high affinity immunoglobulin epsilon receptor signaling in mast cells.|
|Cellular Location||Cytoplasm. Nucleus. Cell membrane. Note=Upon T-cell stimulation, translocates to lipid rafts at the cell membrane|
|Tissue Location||Highly expressed in thymocytes and peripheral blood lymphocytes. Also expressed in spleen cells and testis Present in T-cells (at protein level)|
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Provided below are standard protocols that you may find useful for product applications.
This gene encodes a T cell adaptor protein, a class of intracellular molecules with modular domains capable of recruiting additional proteins but that exhibit no intrinsic enzymatic activity. The encoded protein contains a unique N-terminal region followed by a PH domain and C-terminal SH3 domain. Along with the adhesion and degranulation-promoting adaptor protein, the encoded protein plays a critical role in inside-out signaling by coupling T-cell antigen receptor stimulation to the activation of integrins.
Goode, E.L., et al. Nat. Genet. 42(10):874-879(2010)
Rose, J.E., et al. Mol. Med. 16 (7-8), 247-253 (2010) :
Raab, M., et al. Immunity 32(4):541-556(2010)
Lehmann, R., et al. Proteomics 9(23):5288-5295(2009)
Fang, L., et al. Cell Cycle 8(17):2819-2827(2009)
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