|Application ||WB, E|
|Other Accession||P00884, P79226, Q91Y97, Q3T0S5, NP_000026.2, P52210|
|Predicted||Bovine, Mouse, Rabbit, Rat, Sheep|
|Calculated MW||39473 Da|
|Antigen Region||31-60 aa|
|Other Names||Fructose-bisphosphate aldolase B, Liver-type aldolase, ALDOB, ALDB|
|Target/Specificity||This ALDOB antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 31-60 amino acids from the N-terminal region of human ALDOB.|
|Format||Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||ALDOB Antibody (N-term) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Cellular Location||Cytoplasm, cytoskeleton, microtubule organizing center, centrosome, centriolar satellite|
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Provided below are standard protocols that you may find useful for product applications.
Fructose-1,6-bisphosphate aldolase (EC 22.214.171.124) is a tetrameric glycolytic enzyme that catalyzes the reversible conversion of fructose-1,6-bisphosphate to glyceraldehyde 3-phosphate and dihydroxyacetone phosphate. Vertebrates have 3 aldolase isozymes which are distinguished by their electrophoretic and catalytic properties. Differences indicate that aldolases A, B, and C are distinct proteins, the products of a family of related 'housekeeping' genes exhibiting developmentally regulated expression of the different isozymes. The developing embryo produces aldolase A, which is produced in even greater amounts in adult muscle where it can be as much as 5% of total cellular protein. In adult liver, kidney and intestine, aldolase A expression is repressed and aldolase B is produced. In brain and other nervous tissue, aldolase A and C are expressed about equally. There is a high degree of homology between aldolase A and C. Defects in ALDOB cause hereditary fructose intolerance. [provided by RefSeq].
Bouteldja, N., et al. J. Inherit. Metab. Dis. 33(2):105-112(2010)
Coffee, E.M., et al. J. Inherit. Metab. Dis. 33(1):33-42(2010)
Segat, L., et al. J. Gastroenterol. Hepatol. 24(12):1840-1846(2009)
Davit-Spraul, A., et al. Mol. Genet. Metab. 94(4):443-447(2008)
Eriksson, A., et al. BMC Gastroenterol 8, 34 (2008) :
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