RALGDS Antibody (Center)
Affinity Purified Rabbit Polyclonal Antibody (Pab)
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application
| WB, E |
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Primary Accession | Q12967 |
Other Accession | NP_006257.1 |
Reactivity | Human |
Host | Rabbit |
Clonality | Polyclonal |
Isotype | Rabbit IgG |
Calculated MW | 100607 Da |
Antigen Region | 531-559 aa |
Gene ID | 5900 |
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Other Names | Ral guanine nucleotide dissociation stimulator, RalGDS, Ral guanine nucleotide exchange factor, RalGEF, RALGDS, KIAA1308, RGF |
Target/Specificity | This RALGDS antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 531-559 amino acids from the Central region of human RALGDS. |
Dilution | WB~~1:1000 |
Format | Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification. |
Storage | Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. |
Precautions | RALGDS Antibody (Center) is for research use only and not for use in diagnostic or therapeutic procedures. |
Name | RALGDS |
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Synonyms | KIAA1308, RGF |
Function | Functions as a guanine nucleotide exchange factor (GEF) activating either RalA or RalB GTPases and plays an important role in intracellular transport. Interacts and acts as an effector molecule for R-Ras, H-Ras, K-Ras, and Rap (By similarity). During bacterial clearance, recognizes 'Lys-33'-linked polyubiquitinated TRAF3 and subsequently mediates assembly of the exocyst complex (PubMed:27438768). |
Cellular Location | Cytoplasm {ECO:0000250|UniProtKB:Q03385}. Nucleus {ECO:0000250|UniProtKB:Q03385}. Note=Localizes mainly in the peripheral region of the cytoplasmic membrane in oocytes and in preimplantation embryos until the 8-cell stage. Between the late 1-cell and the early 2-cell stages, nuclear localization becomes stronger. After the 4-cell stage, not detected in the nucleus. {ECO:0000250|UniProtKB:Q03385} |
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Provided below are standard protocols that you may find useful for product applications.
Background
Guanine nucleotide dissociation stimulators (GDSs, or exchange factors), such as RALGDS, are effectors of Ras-related GTPases (see MIM 190020) that participate in signaling for a variety of cellular processes.
References
Fuentes, G., et al. Trends Biochem. Sci. 34(11):533-539(2009)
Maehama, T., et al. J. Biol. Chem. 283(50):35053-35059(2008)
Rondaij, M.G., et al. Blood 112(1):56-63(2008)
Omholt, K., et al. Melanoma Res. 17(6):410-412(2007)
Yin, J., et al. Mol. Cell. Biol. 27(21):7538-7550(2007)
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