|Application ||WB, E|
|Calculated MW||100607 Da|
|Antigen Region||531-559 aa|
|Other Names||Ral guanine nucleotide dissociation stimulator, RalGDS, Ral guanine nucleotide exchange factor, RalGEF, RALGDS, KIAA1308, RGF|
|Target/Specificity||This RALGDS antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 531-559 amino acids from the Central region of human RALGDS.|
|Format||Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||RALGDS Antibody (Center) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Stimulates the dissociation of GDP from the Ras-related RalA and RalB GTPases which allows GTP binding and activation of the GTPases. Interacts and acts as an effector molecule for R-Ras, H-Ras, K-Ras, and Rap.|
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Provided below are standard protocols that you may find useful for product applications.
Guanine nucleotide dissociation stimulators (GDSs, or exchange factors), such as RALGDS, are effectors of Ras-related GTPases (see MIM 190020) that participate in signaling for a variety of cellular processes.
Fuentes, G., et al. Trends Biochem. Sci. 34(11):533-539(2009)
Maehama, T., et al. J. Biol. Chem. 283(50):35053-35059(2008)
Rondaij, M.G., et al. Blood 112(1):56-63(2008)
Omholt, K., et al. Melanoma Res. 17(6):410-412(2007)
Yin, J., et al. Mol. Cell. Biol. 27(21):7538-7550(2007)
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