|Application ||WB, E|
|Calculated MW||57029 Da|
|Antigen Region||275-303 aa|
|Other Names||Fibroblast growth factor receptor substrate 2, FGFR substrate 2, FGFR-signaling adaptor SNT, Suc1-associated neurotrophic factor target 1, SNT-1, FRS2|
|Target/Specificity||This FRS2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 275-303 amino acids from the Central region of human FRS2.|
|Format||Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||FRS2 Antibody (Center) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Adapter protein that links activated FGR and NGF receptors to downstream signaling pathways. Plays an important role in the activation of MAP kinases and in the phosphorylation of PIK3R1, the regulatory subunit of phosphatidylinositol 3- kinase, in response to ligand-mediated activation of FGFR1. Modulates signaling via SHC1 by competing for a common binding site on NTRK1.|
|Cellular Location||Endomembrane system. Note=Cytoplasmic, membrane-bound|
|Tissue Location||Highly expressed in heart, brain, spleen, lung, liver, skeletal muscle, kidney and testis|
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Provided below are standard protocols that you may find useful for product applications.
Adapter protein that links FGR and NGF receptors to downstream signaling pathways. Involved in the activation of MAP kinases. Modulates signaling via SHC1 by competing for a common binding site on NTRK1.
Zhou, W., et al. Cell Res. 19(10):1165-1177(2009)
Cha, J.Y., et al. J. Biol. Chem. 284(10):6227-6240(2009)
Li, M., et al. J. Dermatol. Sci. 53(3):182-191(2009)
Turner, S.T., et al. Hypertension 52(2):359-365(2008)
Gudbjartsson, D.F., et al. Nat. Genet. 40(5):609-615(2008)
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