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>   home   >   Products   >   Primary Antibodies   >   Microbiology   >   SCRIB Antibody (N-term)   

SCRIB Antibody (N-term)

Peptide Affinity Purified Rabbit Polyclonal Antibody (Pab)

  • WB - SCRIB Antibody (N-term) AP18837a
    Anti-SCRIB Antibody (N-term) at 1:2000 dilution + MCF-7 whole cell lysate Lysates/proteins at 20 µg per lane. Secondary Goat Anti-Rabbit IgG, (H+L), Peroxidase conjugated at 1/10000 dilution. Predicted band size : 175 kDa Blocking/Dilution buffer: 5% NFDM/TBST.
  • WB - SCRIB Antibody (N-term) AP18837a
    SCRIB Antibody (N-term)(Cat. #AP18837a) western blot analysis in human placenta tissue lysates (35ug/lane).This demonstrates the SCRIB antibody detected the SCRIB protein (arrow).
Product Information
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
Primary Accession Q14160
Other Accession NP_874365.2
Reactivity Human
Host Rabbit
Clonality Polyclonal
Isotype Rabbit Ig
Calculated MW 174885 Da
Antigen Region 382-410 aa
Additional Information
Gene ID 23513
Other Names Protein scribble homolog, Scribble, hScrib, Protein LAP4, SCRIB, CRIB1, KIAA0147, LAP4, SCRB1, VARTUL
Target/Specificity This SCRIB antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 382-410 amino acids from the N-terminal region of human SCRIB.
Dilution WB~~1:1000
Format Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.
StorageMaintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
PrecautionsSCRIB Antibody (N-term) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Synonyms CRIB1, KIAA0147, LAP4, SCRB1, VARTUL
Function Scaffold protein involved in different aspects of polarized cells differentiation regulating epithelial and neuronal morphogenesis. Most probably functions in the establishment of apico-basal cell polarity. May function in cell proliferation regulating progression from G1 to S phase and as a positive regulator of apoptosis for instance during acinar morphogenesis of the mammary epithelium. May also function in cell migration and adhesion and hence regulate cell invasion through MAPK signaling. May play a role in exocytosis and in the targeting synaptic vesicles to synapses. Functions as an activator of Rac GTPase activity.
Cellular Location Cell membrane; Peripheral membrane protein. Cell junction, adherens junction. Cell projection, lamellipodium Cytoplasm. Note=Targeting to cell-cell junctions which is CDH1- dependent is required for the pro-apoptotic activity. Localizes to neuronal post- and pre-synaptic regions
Tissue Location Expressed in kidney, skeletal muscles, liver, lung, breast, intestine, placenta and skin mainly in epithelial cells (at protein level).
Research Areas
Citations (0)

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SCRIB is a cytoplasmic multimodular scaffold protein targeted to epithelial adherens junctions and neuronal presynaptic compartments. SCRIB and its orthologs in vertebrates and invertebrates participate in cell polarization (summary by Nola et al., 2008 [PubMed 18716323]).


Liu, H., et al. J. Virol. 84(21):11164-11174(2010)
Nagasaka, K., et al. Oncogene 29(38):5311-5321(2010)
Ivanov, A.I., et al. Am. J. Pathol. 176(1):134-145(2010)
Ouyang, Z., et al. Oncol. Res. 18 (11-12), 593-599 (2010) :
Arnaud, C., et al. FEBS Lett. 583(14):2326-2332(2009)

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$ 295.00
$ 99.00
Cat# AP18837a
(40 western blots)
Availability: In Stock
Bulk Size
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