|Application ||WB, E|
|Calculated MW||174885 Da|
|Antigen Region||382-410 aa|
|Other Names||Protein scribble homolog, Scribble, hScrib, Protein LAP4, SCRIB, CRIB1, KIAA0147, LAP4, SCRB1, VARTUL|
|Target/Specificity||This SCRIB antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 382-410 amino acids from the N-terminal region of human SCRIB.|
|Format||Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||SCRIB Antibody (N-term) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Synonyms||CRIB1, KIAA0147, LAP4, SCRB1, VARTUL|
|Function||Scaffold protein involved in different aspects of polarized cells differentiation regulating epithelial and neuronal morphogenesis. Most probably functions in the establishment of apico-basal cell polarity. May function in cell proliferation regulating progression from G1 to S phase and as a positive regulator of apoptosis for instance during acinar morphogenesis of the mammary epithelium. May also function in cell migration and adhesion and hence regulate cell invasion through MAPK signaling. May play a role in exocytosis and in the targeting synaptic vesicles to synapses. Functions as an activator of Rac GTPase activity.|
|Cellular Location||Cell membrane; Peripheral membrane protein. Cell junction, adherens junction. Cell projection, lamellipodium Cytoplasm. Note=Targeting to cell-cell junctions which is CDH1- dependent is required for the pro-apoptotic activity. Localizes to neuronal post- and pre-synaptic regions|
|Tissue Location||Expressed in kidney, skeletal muscles, liver, lung, breast, intestine, placenta and skin mainly in epithelial cells (at protein level).|
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Provided below are standard protocols that you may find useful for product applications.
SCRIB is a cytoplasmic multimodular scaffold protein targeted to epithelial adherens junctions and neuronal presynaptic compartments. SCRIB and its orthologs in vertebrates and invertebrates participate in cell polarization (summary by Nola et al., 2008 [PubMed 18716323]).
Liu, H., et al. J. Virol. 84(21):11164-11174(2010)
Nagasaka, K., et al. Oncogene 29(38):5311-5321(2010)
Ivanov, A.I., et al. Am. J. Pathol. 176(1):134-145(2010)
Ouyang, Z., et al. Oncol. Res. 18 (11-12), 593-599 (2010) :
Arnaud, C., et al. FEBS Lett. 583(14):2326-2332(2009)
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