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KRT31 Antibody (N-term)
Affinity Purified Rabbit Polyclonal Antibody (Pab)
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application 
| WB, E |
|---|---|
| Primary Accession | Q15323 |
| Other Accession | Q14525, O76009, NP_002268.2 |
| Reactivity | Human |
| Host | Rabbit |
| Clonality | Polyclonal |
| Isotype | Rabbit IgG |
| Calculated MW | 47237 Da |
| Antigen Region | 60-89 aa |
| Gene ID | 3881 |
|---|---|
| Other Names | Keratin, type I cuticular Ha1, Hair keratin, type I Ha1, Keratin-31, K31, KRT31, HHA1, HKA1, KRTHA1 |
| Target/Specificity | This KRT31 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 60-89 amino acids from the N-terminal region of human KRT31. |
| Dilution | WB~~1:1000 |
| Format | Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification. |
| Storage | Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. |
| Precautions | KRT31 Antibody (N-term) is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | KRT31 |
|---|---|
| Synonyms | HHA1, HKA1, KRTHA1 |
| Tissue Location | Present in scalp but not in hairless skin. Abundantly expressed in the differentiating cortex of growing (anagen) hair. Expression is restricted to the keratinocytes of the hair cortex and is absent from inner root sheath and medulla |
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Provided below are standard protocols that you may find useful for product applications.
Background
The protein encoded by this gene is a member of the keratin gene family. As a type I hair keratin, it is an acidic protein which heterodimerizes with type II keratins to form hair and nails. The type I hair keratins are clustered in a region of chromosome 17q12-q21 and have the same direction of transcription.
References
Ewing, R.M., et al. Mol. Syst. Biol. 3, 89 (2007) :
Schweizer, J., et al. J. Cell Biol. 174(2):169-174(2006)
Lim, J., et al. Cell 125(4):801-814(2006)
Cribier, B., et al. J. Invest. Dermatol. 122(5):1078-1083(2004)
Langbein, L., et al. J. Biol. Chem. 274(28):19874-19884(1999)
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